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Verfasst von:Heinkele, Franziska [VerfasserIn]   i
 Lou, Bowen [VerfasserIn]   i
 Erben, Vanessa [VerfasserIn]   i
 Bennewitz, Katrin [VerfasserIn]   i
 Poschet, Gernot [VerfasserIn]   i
 Sticht, Carsten [VerfasserIn]   i
 Kroll, Jens [VerfasserIn]   i
Titel:Metabolic and transcriptional adaptations improve physical performance of zebrafish
Verf.angabe:Franziska J. Heinkele, Bowen Lou, Vanessa Erben, Katrin Bennewitz, Gernot Poschet, Carsten Sticht, Jens Kroll
E-Jahr:2021
Jahr:7 October 2021
Umfang:13 S.
Fussnoten:Gesehen am 01.12.2021
Titel Quelle:Enthalten in: Antioxidants
Ort Quelle:Basel : MDPI, 2013
Jahr Quelle:2021
Band/Heft Quelle:10(2021), 10, Artikel-ID 1581, Seite 1-13
ISSN Quelle:2076-3921
Abstract:Obesity is a worldwide public health problem with increasing prevalence and affects 80% of diabetes mellitus type 2 cases. Zebrafish (Danio rerio) is an established model organism for studying obesity and diabetes including diabetic microvascular complications. We aimed to determine whether physical activity is an appropriate tool to examine training effects in zebrafish and to analyse metabolic and transcriptional processes in trained zebrafish. A 2- and 8-week experimental training phase protocol with adult zebrafish in a swim tunnel system was established. We examined zebrafish basic characteristics before and after training such as body weight, body length and maximum speed and considered overfeeding as an additional parameter in the 8-weeks training protocol. Ultimately, the effects of training and overfeeding on blood glucose, muscle core metabolism and liver gene expression using RNA-Seq were investigated. Zebrafish maximum speed was correlated with body length and was significantly increased after 2 weeks of training. Maximum swim speed further increased after 8 weeks of training in both the normal-fed and the overfed groups, but training was found not to be sufficient in preventing weight gain in overfed fish. Metabolome and transcriptome profiling in trained fish exhibited increased blood glucose levels in the short-term and upregulated energy supply pathways as well as response to oxidative stress in the long-term. In conclusion, swim training is a valuable tool to study the effects of physical activity in zebrafish, which is accompanied by metabolic and transcriptional adaptations.
DOI:doi:10.3390/antiox10101581
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/antiox10101581
 Volltext: https://www.mdpi.com/2076-3921/10/10/1581
 DOI: https://doi.org/10.3390/antiox10101581
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:blood glucose
 danio rerio
 diabetes
 metabolomics
 physical activity
 transcriptional profile
K10plus-PPN:1779918771
Verknüpfungen:→ Zeitschrift

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