Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Sievers, Aaron [VerfasserIn]   i
 Sauer, Liane [VerfasserIn]   i
 Hausmann, Michael [VerfasserIn]   i
 Hildenbrand, Georg Lars [VerfasserIn]   i
Titel:Eukaryotic genomes show strong evolutionary conservation of k-mer composition and correlation contributions between introns and intergenic regions
Verf.angabe:Aaron Sievers, Liane Sauer, Michael Hausmann and Georg Hildenbrand
E-Jahr:2021
Jahr:1 October 2021
Umfang:20 S.
Fussnoten:Gesehen am 01.12.2021
Titel Quelle:Enthalten in: Genes
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2021
Band/Heft Quelle:12(2021), 10, Artikel-ID 1571, Seite 1-20
ISSN Quelle:2073-4425
Abstract:Several strongly conserved DNA sequence patterns in and between introns and intergenic regions (IIRs) consisting of short tandem repeats (STRs) with repeat lengths <3 bp have already been described in the kingdom of Animalia. In this work, we expanded the search and analysis of conserved DNA sequence patterns to a wider range of eukaryotic genomes. Our aims were to confirm the conservation of these patterns, to support the hypothesis on their functional constraints and/or the identification of unknown patterns. We pairwise compared genomic DNA sequences of genes, exons, CDS, introns and intergenic regions of 34 Embryophyta (land plants), 30 Protista and 29 Fungi using established k-mer-based (alignment-free) comparison methods. Additionally, the results were compared with values derived for Animalia in former studies. We confirmed strong correlations between the sequence structures of IIRs spanning over the entire domain of Eukaryotes. We found that the high correlations within introns, intergenic regions and between the two are a result of conserved abundancies of STRs with repeat units ≤2 bp (e.g., (AT)n). For some sequence patterns and their inverse complementary sequences, we found a violation of equal distribution on complementary DNA strands in a subset of genomes. Looking at mismatches within the identified STR patterns, we found specific preferences for certain nucleotides stable over all four phylogenetic kingdoms. We conclude that all of these conserved patterns between IIRs indicate a shared function of these sequence structures related to STRs.
DOI:doi:10.3390/genes12101571
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/genes12101571
 Volltext: https://www.mdpi.com/2073-4425/12/10/1571
 DOI: https://doi.org/10.3390/genes12101571
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:k-mer
 3D conformation of DNA
 alignment-free
 eukaryotes
 evolution
 genome
 intergenic region
 intron
 sequence analysis
 sequence patterns
 short tandem repeats (STRs)
K10plus-PPN:1779957343
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68807045   QR-Code
zum Seitenanfang