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Status: Bibliographieeintrag

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Verfasst von:Platzman, Ilia [VerfasserIn]   i
 Janiesch, Jan-Willi [VerfasserIn]   i
 Matić, Jovana [VerfasserIn]   i
 Spatz, Joachim P. [VerfasserIn]   i
Titel:Artificial antigen-presenting interfaces in the service of immunology
Verf.angabe:Ilia Platzman, Jan-Willi Janiesch, Jovana Matić, and Joachim P. Spatz
E-Jahr:2013
Jahr:September 16, 2013
Umfang:15 S.
Fussnoten:Gesehen am 02.12.2021
Titel Quelle:Enthalten in: Israel journal of chemistry
Ort Quelle:Weinheim : Wiley-VCH, 1963
Jahr Quelle:2013
Band/Heft Quelle:53(2013), 9/10 vom: Okt., Seite 655-669
ISSN Quelle:1869-5868
Abstract:While the beneficial impact of modifying and/or targeting T lymphocytes is becoming increasingly accepted in the treatment of different diseases, the road towards cell-based immunotherapy is still long and winding. Major challenges that remain include, amongst others, the guidance and exquisite regulation of immune processes ex vivo. In part, this is due to the difficulties of simulating ex vivo the intimate cellular interactions that occur between T cells and antigen-presenting cells (APCs). The fate of T cells is not solely regulated by the presence of certain molecules on the surface of APCs but also by their density and spatial distribution on the micro- and nanometric scale. Moreover, mechanical properties of APCs and force-dependent conformational changes during the formation of an immunological synapse (IS; a highly organized supramolecular complex at the T cellAPC interface), play a crucial role in T cell fate regulation. Various different technical means have been developed to create APC substitutes that are able to simulate ex vivo signals originating from naturally occurring APCs. Here, we review the performance of APC surrogates and discuss their contribution to understanding mechanisms underlying the ability of T cells to perform the “intelligent” mission of acquiring, processing and responding to environmental information.
DOI:doi:10.1002/ijch.201300060
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/ijch.201300060
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijch.201300060
 DOI: https://doi.org/10.1002/ijch.201300060
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:antigens
 cell recognition
 immunology
 nanostructures
 T cells
K10plus-PPN:1780072872
Verknüpfungen:→ Zeitschrift

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