| |  Online-Ressource |
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| Verfasst von: | Krämer, Alwin [VerfasserIn]  |
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| | Schweizer, Silja [VerfasserIn] |
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| | Neben, Kai [VerfasserIn] |
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| | Giesecke, Christian [VerfasserIn] |
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| | Kalla, J. [VerfasserIn] |
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| | Katzenberger, T. [VerfasserIn] |
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| | Benner, Axel [VerfasserIn] |
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| | Müller-Hermelink, H. K. [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Ott, G. [VerfasserIn] |
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| Titel: | Centrosome aberrations as a possible mechanism for chromosomal instability in non-Hodgkin's lymphoma |
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| Verf.angabe: | A. Krämer, S. Schweizer, K. Neben, C. Giesecke, J. Kalla, T. Katzenberger, A. Benner, H.K. Müller-Hermelink, A.D. Ho and G. Ott |
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| E-Jahr: | 2003 |
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| Jahr: | 18 September 2003 |
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| Umfang: | 7 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 03.12.2021 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2003 |
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| Band/Heft Quelle: | 17(2003), 11, Seite 2207-2213 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | Recently, centrosome aberrations have been described as a possible cause of aneuploidy in many solid tumors. To investigate whether centrosome aberrations occur in non-Hodgkin's lymphoma (NHL) and correlate with histologic subtype, karyotype, and other biological disease features, we examined 24 follicular lymphomas (FL), 18 diffuse large-B-cell lymphomas (DLCL), 33 mantle cell lymphomas (MCL), and 17 extranodal marginal zone B-cell lymphomas (MZBCL), using antibodies to centrosomal proteins. All 92 NHL displayed numerical and structural centrosome aberrations as compared to nonmalignant lymphoid tissue. Centrosome abnormalities were detectable in 32.3% of the cells in NHL, but in only 5.5% of lymphoid cells from 30 control individuals (P<0.0001). Indolent FL and MZBCL contained only 25.8 and 28.8% cells with abnormal centrosomes. In contrast, aggressive DLCL and MCL harbored centrosome aberrations in 41.8 and 35.0% of the cells, respectively (P<0.0001). Centrosomal aberrations correlated to lymphoma grade, mitotic, and proliferation indices, but not to the p53 labeling index. Importantly, diploid MCL contained 31.2% cells with abnormal centrosomes, while tetraploid samples harbored centrosome aberrations in 55.6% of the cells (P<0.0001). These results indicate that centrosome defects are common in NHL and suggest that they may contribute to the acquisition of chromosomal instability typically seen in NHL. |
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| DOI: | doi:10.1038/sj.leu.2403142 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/sj.leu.2403142 |
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| | Volltext: https://www.nature.com/articles/2403142 |
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| | DOI: https://doi.org/10.1038/sj.leu.2403142 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer Research |
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| | general |
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| | Hematology |
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| | Intensive / Critical Care Medicine |
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| | Internal Medicine |
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| | Medicine/Public Health |
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| | Oncology |
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| K10plus-PPN: | 1780210329 |
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| Verknüpfungen: | → Zeitschrift |
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Centrosome aberrations as a possible mechanism for chromosomal instability in non-Hodgkin's lymphoma / Krämer, Alwin [VerfasserIn]; 18 September 2003 (Online-Ressource)
