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| Verfasst von: | Pooley, Karen A. [VerfasserIn]  |
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| | Bojesen, Stig E. [VerfasserIn] |
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| | Weischer, Maren [VerfasserIn] |
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| | Nielsen, Sune F. [VerfasserIn] |
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| | Thompson, Deborah [VerfasserIn] |
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| | Amin Al Olama, Ali [VerfasserIn] |
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| | Michailidou, Kyriaki [VerfasserIn] |
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| | Tyrer, Jonathan P. [VerfasserIn] |
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| | Benlloch, Sara [VerfasserIn] |
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| | Brown, Judith [VerfasserIn] |
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| | Audley, Tina [VerfasserIn] |
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| | Luben, Robert [VerfasserIn] |
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| | Khaw, K-T [VerfasserIn] |
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| | Neal, David E. [VerfasserIn] |
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| | Hamdy, Freddie C. [VerfasserIn] |
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| | Donovan, Jenny L. [VerfasserIn] |
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| | Kote-Jarai, Zsofia [VerfasserIn] |
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| | Baynes, Caroline [VerfasserIn] |
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| | Shah, Mitul [VerfasserIn] |
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| | Bolla, Manjeet K. [VerfasserIn] |
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| | Wang, Qin [VerfasserIn] |
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| | Dennis, Joe [VerfasserIn] |
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| | Dicks, Ed [VerfasserIn] |
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| | Yang, Rongxi [VerfasserIn] |
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| | Rudolph, Anja [VerfasserIn] |
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| | Schildkraut, Joellen [VerfasserIn] |
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| | Chang-Claude, Jenny [VerfasserIn] |
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| | Burwinkel, Barbara [VerfasserIn] |
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| | Chenevix-Trench, Georgia [VerfasserIn] |
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| | Pharoah, Paul D. P. [VerfasserIn] |
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| | Berchuck, Andrew [VerfasserIn] |
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| | Eeles, Rosalind A. [VerfasserIn] |
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| | Easton, Douglas F. [VerfasserIn] |
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| | Dunning, Alison M. [VerfasserIn] |
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| | Nordestgaard, Børge G. [VerfasserIn] |
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| Titel: | A genome-wide association scan (GWAS) for mean telomere length within the COGS project |
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| Titelzusatz: | identified loci show little association with hormone-related cancer risk |
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| Verf.angabe: | Karen A. Pooley, Stig E. Bojesen, Maren Weischer, Sune F. Nielsen, Deborah Thompson, Ali Amin Al Olama, Kyriaki Michailidou, Jonathan P. Tyrer, Sara Benlloch, Judith Brown, Tina Audley, Robert Luben, K-T Khaw, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Zsofia Kote-Jarai, Caroline Baynes, Mitul Shah, Manjeet K. Bolla, Qin Wang, Joe Dennis, Ed Dicks, Rongxi Yang, Anja Rudolph, Joellen Schildkraut, Jenny Chang-Claude, Barbara Burwinkel, Georgia Chenevix-Trench, Paul D. P. Pharoah, Andrew Berchuck, Rosalind A. Eeles, Douglas F. Easton, Alison M. Dunning, Børge G. Nordestgaard |
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| E-Jahr: | 2013 |
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| Jahr: | July 29, 2013 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 06.12.2021 |
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| Titel Quelle: | Enthalten in: Human molecular genetics |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1992 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 22(2013), 24 vom: 15. Dez., Seite 5056-5064 |
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| ISSN Quelle: | 1460-2083 |
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| Abstract: | Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the “iCOGS” custom genotyping array. All ∼200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were further tested in breast cancer cases (n = 11 024). We found a novel TL association (Ptrend < 4 × 10−10) at 3p14.4 close to PXK and evidence (Ptrend < 7 × 10−7) for TL loci at 6p22.1 (ZNF311) and 20q11.2 (BCL2L1). We additionally confirmed (Ptrend < 5 × 10−14) the previously reported loci at 3q26.2 (TERC), 5p15.3 (TERT) and 10q24.3 (OBFC1) and found supportive evidence (Ptrend < 5 × 10−4) for the published loci at 2p16.2 (ACYP2), 4q32.2 (NAF1) and 20q13.3 (RTEL1). SNPs tagging these loci explain TL differences of up to 731 bp (corresponding to 18% of total TL in healthy individuals), however, they display little direct evidence for association with breast, ovarian or prostate cancer risks. |
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| DOI: | doi:10.1093/hmg/ddt355 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1093/hmg/ddt355 |
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| | Volltext: https://academic.oup.com/hmg/article/22/24/5056/569757 |
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| | DOI: https://doi.org/10.1093/hmg/ddt355 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1780379226 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ genome-wide association scan (GWAS) for mean telomere length within the COGS project / Pooley, Karen A. [VerfasserIn]; July 29, 2013 (Online-Ressource)
