Dark corner artefact and diagnostic performance of a market-approved neural network for skin cancer classification

• Verfasst von: Kommoss, Katharina [VerfasserIn]
• Verfasst von: Winkler, Julia K. [VerfasserIn]
• Verfasst von: Müller-Christmann, Christine [VerfasserIn]
• Verfasst von: Niedermair, Felicitas [VerfasserIn]
• Verfasst von: Toberer, Ferdinand [VerfasserIn]
• Verfasst von: Kommoss, Felix [VerfasserIn]
• Verfasst von: Buhl, Timo [VerfasserIn]
• Verfasst von: Enk, Alexander [VerfasserIn]
• Verfasst von: Rosenberger, Albert [VerfasserIn]
• Verfasst von: Hänßle, Holger [VerfasserIn]
• Titel: Dark corner artefact and diagnostic performance of a market-approved neural network for skin cancer classification
• Verf.angabe: Katharina Sies, Julia K. Winkler, Christine Fink, Felicitas Bardehle, Ferdinand Toberer, Felix K.F. Kommoss, Timo Buhl, Alexander Enk, Albert Rosenberger, Holger A. Haenssle
• Jahr: 2021
• Umfang: 9 S.
• Fussnoten: First published: 10 May 2021 ; Gesehen am 06.12.2021
• Titel Quelle: Enthalten in: Deutsche Dermatologische GesellschaftJournal der Deutschen Dermatologischen Gesellschaft
• Ort Quelle: Berlin : Wiley-Blackwell, 2003
• Jahr Quelle: 2021
• Band/Heft Quelle: 19(2021), 6, Seite 842-850
• ISSN Quelle: 1610-0387
• DOI: doi:10.1111/ddg.14384
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1780387431
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Background and objectives Convolutional neural networks (CNN) have proven dermatologist-level performance in skin lesion classification. Prior to a broader clinical application, an assessment of limitations is crucial. Therefore, the influence of a dark tubular periphery in dermatoscopic images (also called dark corner artefact [DCA]) on the diagnostic performance of a market-approved CNN for skin lesion classification was investigated. Patients and methods A prospective image set of 233 skin lesions (60 malignant, 173 benign) without DCA (control-set) was modified to show small, medium or large DCA. All 932 images were analyzed by a market-approved CNN (Moleanalyzer-Pro®, FotoFinder Systems), providing malignancy scores (range 0-1) with the cut-off > 0.5 indicating malignancy. Results In the control-set the CNN achieved a sensitivity of 90.0 % (79.9 % - 95.3 %), a specificity of 96.5 % (92.6 % - 98.4 %), and an area under the curve (AUC) of receiver operating characteristics (ROC) of 0.961 (0.932 - 0.989). Comparable diagnostic performance was observed in the DCAsmall-set and DCAmedium-set. Conversely, in the DCAlarge-set significantly increased malignancy scores triggered a significantly decreased specificity (87.9 % [82.2 % - 91.9 %], P < 0.001), non-significantly increased sensitivity (96.7 % [88.6 % - 99.1 %]) and unchanged ROC-AUC of 0.962 (0.935 - 0.989). Conclusions Convolutional neural network classification was robust in images with small and medium DCA, but impaired in images with large DCA. Physicians should be aware of this limitation when submitting images to CNN classification.