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| Verfasst von: | Korkmaz-İçöz, Sevil [VerfasserIn]  |
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| | Ballikaya, Belinda [VerfasserIn] |
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| | Soethoff, Jasmin [VerfasserIn] |
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| | Kraft, Patricia [VerfasserIn] |
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| | Sayour, Alex Ali [VerfasserIn] |
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| | Radovits, Tamás [VerfasserIn] |
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| | Loganathan, Sivakkanan [VerfasserIn] |
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| | Karck, Matthias [VerfasserIn] |
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| | Szabó, Gábor [VerfasserIn] |
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| | Veres, Gábor [VerfasserIn] |
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| Titel: | Graft preservation solution DuraGraft® alleviates vascular dysfunction following in vitro ischemia/reperfusion injury in rats |
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| Verf.angabe: | Sevil Korkmaz-Icöz, Belinda Ballikaya, Jasmin Soethoff, Patricia Kraft, Alex Ali Sayour, Tamás Radovits, Sivakkanan Loganathan, Matthias Karck, Gábor Szabó and Gábor Veres |
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| E-Jahr: | 2021 |
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| Jahr: | 9 October 2021 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 06.12.2021 |
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| Titel Quelle: | Enthalten in: Pharmaceuticals |
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| Ort Quelle: | Basel : MDPI, 2004 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 14(2021), 10, Artikel-ID 1028, Seite 1-9 |
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| ISSN Quelle: | 1424-8247 |
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| Abstract: | Vascular ischemia/reperfusion injury (IRI) in patients undergoing coronary artery bypass grafting can result in graft failure and the need for repeat revascularization procedures. DuraGraft® has been shown to protect structure and function in saphenous vein grafts against IRI. We compared the effect of DuraGraft® to saline solution on arterial grafts submitted to IRI. Rat thoracic aortic rings were harvested and immediately mounted in organ bath chambers (control, n = 7 rats) or underwent cold ischemic preservation either in saline (IR, n = 9 rats) or DuraGraft® (IR+Dura, n = 9 rats). Vascular function was measured ex vivo and immunohistochemistry was performed. Impaired maximum vasorelaxation (Rmax) to ACh in the IR-group compared to controls was ameliorated by DuraGraft®, indicating an improvement in endothelial function (Rmax to ACh (%): IR + Dura 73 ± 2 vs. IR 48 ± 3, p < 0.05). Additionally, decreased aortic ring sensitivity to ACh (pD2-value: -log 50% maximum response) seen after IR in the saline group was increased by DuraGraft® (pD2 to ACh: IR+Dura 7.1 ± 0.1 vs. IR 6.3 ± 0.2, p < 0.05). Impaired maximum contractile response to phenylephrine and high potassium chloride concentrations in the IR group compared to controls was significantly improved by DuraGraft®. DuraGraft® alleviates vascular dysfunction following IRI by reducing nitro-oxidative stress and the expression of ICAM-1, without leukocytes engagement. |
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| DOI: | doi:10.3390/ph14101028 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ph14101028 |
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| | Volltext: https://www.mdpi.com/1424-8247/14/10/1028 |
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| | DOI: https://doi.org/10.3390/ph14101028 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | coronary artery bypass grafting |
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| | DuraGraft® |
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| | endothelial function |
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| | ischemia/reperfusion |
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| K10plus-PPN: | 1780403798 |
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| Verknüpfungen: | → Zeitschrift |
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Graft preservation solution DuraGraft® alleviates vascular dysfunction following in vitro ischemia/reperfusion injury in rats / Korkmaz-İçöz, Sevil [VerfasserIn]; 9 October 2021 (Online-Ressource)
