Challenges of neuropathic pain

• Verfasst von: Rosenberger, Daniela C. [VerfasserIn]
• Verfasst von: Blechschmidt, Vivian [VerfasserIn]
• Verfasst von: Timmerman, Hans [VerfasserIn]
• Verfasst von: Wolff, André [VerfasserIn]
• Verfasst von: Treede, Rolf-Detlef [VerfasserIn]
• Titel: Challenges of neuropathic pain
• Titelzusatz: focus on diabetic neuropathy
• Verf.angabe: Daniela C. Rosenberger, Vivian Blechschmidt, Hans Timmerman, André Wolff, Rolf-Detlef Treede
• E-Jahr: 2020
• Jahr: 08 February 2020
• Umfang: 36 S.
• Fussnoten: Gesehen am 06.12.2021
• Titel Quelle: Enthalten in: Journal of neural transmission
• Ort Quelle: Wien [u.a.] : Springer, 1950
• Jahr Quelle: 2020
• Band/Heft Quelle: 127(2020), 4, Seite 589-624
• ISSN Quelle: 1435-1463
• DOI: doi:10.1007/s00702-020-02145-7
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1780466773
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain is diabetic neuropathy. Its complex pathophysiology is not yet fully elucidated, which contributes to underassessment and undertreatment. A mechanism-based treatment of painful diabetic neuropathy is challenging but phenotype-based stratification might be a way to develop individualized therapeutic concepts. Our goal is to review current knowledge of the pathophysiology of peripheral neuropathic pain, particularly painful diabetic neuropathy. We discuss state-of-the-art clinical assessment, validity of diagnostic and screening tools, and recommendations for the management of diabetic neuropathic pain including approaches towards personalized pain management. We also propose a research agenda for translational research including patient stratification for clinical trials and improved preclinical models in relation to current knowledge of underlying mechanisms.