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Verfasst von:Rosenberger, Daniela C. [VerfasserIn]   i
 Blechschmidt, Vivian [VerfasserIn]   i
 Timmerman, Hans [VerfasserIn]   i
 Wolff, André [VerfasserIn]   i
 Treede, Rolf-Detlef [VerfasserIn]   i
Titel:Challenges of neuropathic pain
Titelzusatz:focus on diabetic neuropathy
Verf.angabe:Daniela C. Rosenberger, Vivian Blechschmidt, Hans Timmerman, André Wolff, Rolf-Detlef Treede
E-Jahr:2020
Jahr:08 February 2020
Umfang:36 S.
Fussnoten:Gesehen am 06.12.2021
Titel Quelle:Enthalten in: Journal of neural transmission
Ort Quelle:Wien [u.a.] : Springer, 1950
Jahr Quelle:2020
Band/Heft Quelle:127(2020), 4, Seite 589-624
ISSN Quelle:1435-1463
Abstract:Neuropathic pain is a frequent condition caused by a lesion or disease of the central or peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain is diabetic neuropathy. Its complex pathophysiology is not yet fully elucidated, which contributes to underassessment and undertreatment. A mechanism-based treatment of painful diabetic neuropathy is challenging but phenotype-based stratification might be a way to develop individualized therapeutic concepts. Our goal is to review current knowledge of the pathophysiology of peripheral neuropathic pain, particularly painful diabetic neuropathy. We discuss state-of-the-art clinical assessment, validity of diagnostic and screening tools, and recommendations for the management of diabetic neuropathic pain including approaches towards personalized pain management. We also propose a research agenda for translational research including patient stratification for clinical trials and improved preclinical models in relation to current knowledge of underlying mechanisms.
DOI:doi:10.1007/s00702-020-02145-7
URL:kostenfrei: Volltext: https://doi.org/10.1007/s00702-020-02145-7
 DOI: https://doi.org/10.1007/s00702-020-02145-7
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1780466773
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