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| Online-Ressource |
Verfasst von: | Rosenberger, Daniela C. [VerfasserIn]  |
| Blechschmidt, Vivian [VerfasserIn]  |
| Timmerman, Hans [VerfasserIn]  |
| Wolff, André [VerfasserIn]  |
| Treede, Rolf-Detlef [VerfasserIn]  |
Titel: | Challenges of neuropathic pain |
Titelzusatz: | focus on diabetic neuropathy |
Verf.angabe: | Daniela C. Rosenberger, Vivian Blechschmidt, Hans Timmerman, André Wolff, Rolf-Detlef Treede |
E-Jahr: | 2020 |
Jahr: | 08 February 2020 |
Umfang: | 36 S. |
Fussnoten: | Gesehen am 06.12.2021 |
Titel Quelle: | Enthalten in: Journal of neural transmission |
Ort Quelle: | Wien [u.a.] : Springer, 1950 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 127(2020), 4, Seite 589-624 |
ISSN Quelle: | 1435-1463 |
Abstract: | Neuropathic pain is a frequent condition caused by a lesion or disease of the central or peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain is diabetic neuropathy. Its complex pathophysiology is not yet fully elucidated, which contributes to underassessment and undertreatment. A mechanism-based treatment of painful diabetic neuropathy is challenging but phenotype-based stratification might be a way to develop individualized therapeutic concepts. Our goal is to review current knowledge of the pathophysiology of peripheral neuropathic pain, particularly painful diabetic neuropathy. We discuss state-of-the-art clinical assessment, validity of diagnostic and screening tools, and recommendations for the management of diabetic neuropathic pain including approaches towards personalized pain management. We also propose a research agenda for translational research including patient stratification for clinical trials and improved preclinical models in relation to current knowledge of underlying mechanisms. |
DOI: | doi:10.1007/s00702-020-02145-7 |
URL: | kostenfrei: Volltext: https://doi.org/10.1007/s00702-020-02145-7 |
| DOI: https://doi.org/10.1007/s00702-020-02145-7 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1780466773 |
Verknüpfungen: | → Zeitschrift |
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Lokale URL UB: | Zum Volltext |
Challenges of neuropathic pain / Rosenberger, Daniela C. [VerfasserIn]; 08 February 2020 (Online-Ressource)
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