| Online-Ressource |
Verfasst von: | Preusser, Matthias [VerfasserIn]  |
| Berghoff, Anna S. [VerfasserIn]  |
| Ilhan-Mutlu, Aysegül [VerfasserIn]  |
| Dinhof, Carina [VerfasserIn]  |
| Magerle, Manuel [VerfasserIn]  |
| Marosi, Christine [VerfasserIn]  |
| Hejna, Michael [VerfasserIn]  |
| Capper, David [VerfasserIn]  |
| Deimling, Andreas von [VerfasserIn]  |
| Schoppmann, Sebastian F. [VerfasserIn]  |
| Birner, Peter [VerfasserIn]  |
Titel: | Brain metastases of gastro-oesophageal cancer |
Titelzusatz: | evaluation of molecules with relevance for targeted therapies |
Verf.angabe: | Matthias Preusser, Anna S. Berghoff, Aysegül Ilhan-Mutlu, Carina Dinhof, Manuel Magerle, Christine Marosi, Michael Hejna, David Capper, Andreas Von Deimling, Sebastian F. Schoppmann and Peter Birner |
E-Jahr: | 2013 |
Jahr: | March 11, 2013 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 08.12.2021 ; keine DOI! |
Titel Quelle: | Enthalten in: Anticancer research |
Ort Quelle: | Attiki, 2004 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 33(2013), 3 vom: März, Seite 1065-1071 |
ISSN Quelle: | 1791-7530 |
Abstract: | Background: Brain metastases (BM) of gastro-oesophageal cancer are exceedingly rare and only limited data exist on their pathobiology. Materials and Methods: We identified tissue samples of BM of gastro-oesophageal cancer and analyzed the expression of human epidermal growth factor receptor-2 (HER2), phosphorylated signal transducer and activator of transcription-3 (pSTAT3), epithelial growth factor receptor (EGFR), V600E point mutation of the v-raf murine sarcoma viral oncogene homolog-B1 (BRAF V600E), cluster of differentiation molecule-34 (CD34), hypoxia inducible factor-1α (HIF 1-α) and Ki-67 by immunohistochemical methods. Results: Our series comprised of twenty adenocarcinomas and one oesophageal squamous cell carcinoma. Three (14%), 7 (33%), 9 (43%), 18 (86%) and 0 BM specimens were scored positively for HER2, EGFR, pSTAT3, HIF1-α and BRAF V600E expression. The median Ki-67 index was 59%. The microvascular density was moderate-to-high and active intratumoral microvascular sprouting was evident in 20/21 (95%) of BMs. The HER2 and EGFR expression status were consistent between primary tumors and BM in all three assessable cases. HIF1-α and pSTAT3 expression were significantly higher in HER2-positive cases. Conclusion: Therapeutic use of agents targeting HER2, pSTAT3, EGFR and angiogenesis may be feasible for selected BM of gastro-esophageal cancer. HER2 positivity does not seem to predispose to brain colonization in gastro-esophageal cancer. |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://ar.iiarjournals.org/content/33/3/1065 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Brain metastases |
| gastro-oesophageal cancer |
| GI cancer |
| molecules |
| targeted therapy |
K10plus-PPN: | 1780703597 |
Verknüpfungen: | → Zeitschrift |
Brain metastases of gastro-oesophageal cancer / Preusser, Matthias [VerfasserIn]; March 11, 2013 (Online-Ressource)