Brain metastases of gastro-oesophageal cancer

• Verfasst von: Preusser, Matthias [VerfasserIn]
• Verfasst von: Berghoff, Anna S. [VerfasserIn]
• Verfasst von: Ilhan-Mutlu, Aysegül [VerfasserIn]
• Verfasst von: Dinhof, Carina [VerfasserIn]
• Verfasst von: Magerle, Manuel [VerfasserIn]
• Verfasst von: Marosi, Christine [VerfasserIn]
• Verfasst von: Hejna, Michael [VerfasserIn]
• Verfasst von: Capper, David [VerfasserIn]
• Verfasst von: Deimling, Andreas von [VerfasserIn]
• Verfasst von: Schoppmann, Sebastian F. [VerfasserIn]
• Verfasst von: Birner, Peter [VerfasserIn]
• Titel: Brain metastases of gastro-oesophageal cancer
• Titelzusatz: evaluation of molecules with relevance for targeted therapies
• Verf.angabe: Matthias Preusser, Anna S. Berghoff, Aysegül Ilhan-Mutlu, Carina Dinhof, Manuel Magerle, Christine Marosi, Michael Hejna, David Capper, Andreas Von Deimling, Sebastian F. Schoppmann and Peter Birner
• E-Jahr: 2013
• Jahr: March 11, 2013
• Umfang: 7 S.
• Fussnoten: Gesehen am 08.12.2021 ; keine DOI!
• Titel Quelle: Enthalten in: Anticancer research
• Ort Quelle: Attiki, 2004
• Jahr Quelle: 2013
• Band/Heft Quelle: 33(2013), 3 vom: März, Seite 1065-1071
• ISSN Quelle: 1791-7530
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Brain metastases
• Sach-SW: gastro-oesophageal cancer
• Sach-SW: GI cancer
• Sach-SW: molecules
• Sach-SW: targeted therapy
• K10plus-PPN: 1780703597

Abstract

Background: Brain metastases (BM) of gastro-oesophageal cancer are exceedingly rare and only limited data exist on their pathobiology. Materials and Methods: We identified tissue samples of BM of gastro-oesophageal cancer and analyzed the expression of human epidermal growth factor receptor-2 (HER2), phosphorylated signal transducer and activator of transcription-3 (pSTAT3), epithelial growth factor receptor (EGFR), V600E point mutation of the v-raf murine sarcoma viral oncogene homolog-B1 (BRAF V600E), cluster of differentiation molecule-34 (CD34), hypoxia inducible factor-1α (HIF 1-α) and Ki-67 by immunohistochemical methods. Results: Our series comprised of twenty adenocarcinomas and one oesophageal squamous cell carcinoma. Three (14%), 7 (33%), 9 (43%), 18 (86%) and 0 BM specimens were scored positively for HER2, EGFR, pSTAT3, HIF1-α and BRAF V600E expression. The median Ki-67 index was 59%. The microvascular density was moderate-to-high and active intratumoral microvascular sprouting was evident in 20/21 (95%) of BMs. The HER2 and EGFR expression status were consistent between primary tumors and BM in all three assessable cases. HIF1-α and pSTAT3 expression were significantly higher in HER2-positive cases. Conclusion: Therapeutic use of agents targeting HER2, pSTAT3, EGFR and angiogenesis may be feasible for selected BM of gastro-esophageal cancer. HER2 positivity does not seem to predispose to brain colonization in gastro-esophageal cancer.