Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Schröder, Johannes [VerfasserIn]  |
| Bubeck, Bernd [VerfasserIn]  |
| Demisch, Sibylle [VerfasserIn]  |
| Sauer, Heinrich [VerfasserIn]  |
Titel: | Benzodiazepine receptor distribution and diazepam binding in schizophrenia |
Titelzusatz: | an exploratory study |
Verf.angabe: | Johannes Schröder, Bernd Bubeck, Sibylle Demisch, Heinrich Sauer |
Jahr: | 1997 |
Umfang: | 7 S. |
Fussnoten: | Elektronische Reproduktion der Druck-Ausgabe 25. März 1999 ; Gesehen am 09.12.2021 |
Titel Quelle: | Enthalten in: Psychiatry research |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1979 |
Jahr Quelle: | 1997 |
Band/Heft Quelle: | 68(1997), 2, Seite 125-131 |
ISSN Quelle: | 1872-7123 |
Abstract: | Clinical studies indicate that patients with acute schizophrenia may benefit from benzodiazepine treatment. Therefore we investigated the benzodiazepine receptor distribution and diazepam binding in 20 patients with DSM-III schizophrenia using single photon emission computed tomography (SPECT) with iomazenil as the ligand. In each patient, two SPECT images were obtained: SPECT 1 was obtained 2 h after intravenous injection of 200 MBq I-123-iomazenil. Following SPECT 1, patients received 10 mg diazepam intravenously. Twenty min later, SPECT 2 was started. The highest iomazenil uptake was found in the occipital cortex followed by the frontal and temporal cortices. Baseline iomazenil uptake in the medial frontal cortex was significantly (P < 0.05) correlated with the BPRS total score (r = 0.46). Diazepam injection led to a significant activity decrease in iomazenil binding which was greatest in the frontal regions of interest. With respect to the medial frontal cortex, this effect was significantly (P < 0.05) more pronounced in patients with a remitting than a chronic course of the disorder. These findings suggest that changes of the benzodiazepine receptor system in the frontal cortex may be associated with severity and chronicity of schizophrenia. |
DOI: | doi:10.1016/S0925-4927(96)02843-0 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/S0925-4927(96)02843-0 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0925492796028430 |
| DOI: https://doi.org/10.1016/S0925-4927(96)02843-0 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Diazepam |
| GABA |
| Schizophrenia |
| SPECT |
K10plus-PPN: | 178084980X |
Verknüpfungen: | → Zeitschrift |
Benzodiazepine receptor distribution and diazepam binding in schizophrenia / Schröder, Johannes [VerfasserIn]; 1997 (Online-Ressource)
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