Kinetics of peripheral blood stem cell mobilization following G-CSF-supported chemotherapy

• Verfasst von: Seggewiß, Ruth [VerfasserIn]
• Verfasst von: Buß, Eike Christian [VerfasserIn]
• Verfasst von: Herrmann, Doris [VerfasserIn]
• Verfasst von: Goldschmidt, Hartmut [VerfasserIn]
• Verfasst von: Ho, Anthony Dick [VerfasserIn]
• Verfasst von: Frühauf, Stefan [VerfasserIn]
• Titel: Kinetics of peripheral blood stem cell mobilization following G-CSF-supported chemotherapy
• Verf.angabe: Ruth Seggewiss, Eike Christian Buss, Doris Herrmann, Hartmut Goldschmidt, Anthony Dick Ho, Stefan Fruehauf
• E-Jahr: 2003
• Jahr: [September 2003]
• Umfang: 7 S.
• Illustrationen: 1 Diagramm
• Fussnoten: Elektronische Reproduktion der Druckausgabe ; Gesehen am 10.12.2021
• Titel Quelle: Enthalten in: Stem cells
• Ort Quelle: Hoboken, NJ : Wiley-Blackwell, 1983
• Jahr Quelle: 2003
• Band/Heft Quelle: 21(2003), 5, Seite 568-574
• ISSN Quelle: 1549-4918
• DOI: doi:10.1634/stemcells.21-5-568
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: CD34+
• Sach-SW: Mobilization kinetics
• Sach-SW: Peripheral blood stem cell collection
• Sach-SW: Poor mobilizer
• Sach-SW: Premobilization therapy
• K10plus-PPN: 1780924828

Abstract

It would be a clinical and economical advantage if the optimal time point of peripheral blood stem cell (PBSC) mobilization following G-CSF-supported chemotherapy (CT) was known in advance. Therefore, we retrospectively analyzed mobilization parameters in 113 adult tumor patients treated in our institution within 1 year. The start of apheresis was guided by CD34+ cell measurements in the PB and occurred on or after day 11 after start of mobilization CT in 97% of patients. The median peak (p)CD34+ cell count in PB uniformly occurred on day 14-15 (range: 6-32 days) after the start of CT, irrespective of the diagnosis (multiple myeloma n = 76, other histology n = 37), the type, but not the amount, of premobilization CT or radiotherapy (RT), the mobilization regimen, or the G-CSF dosage administered. Among more heavily pretreated patients (>six cycles of prior CT or RT), a higher proportion mobilized late (pCD34+ cell count later than day 20 in 12% and 13%, respectively, versus 2%-5% in the other groups). Therefore, we propose to start measuring CD34+ cells in the PB on day 11 after the start of mobilization therapy. The wide range of optimal mobilization time points argues for an individualized rather than a preset start of apheresis.