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Verfasst von:Rottenburger, Christof [VerfasserIn]   i
 Kiel, Katja [VerfasserIn]   i
 Bösing, Tobias [VerfasserIn]   i
 Cremer, Friedrich Walter [VerfasserIn]   i
 Moldenhauer, Gerhard [VerfasserIn]   i
 Ho, Anthony Dick [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Moos, Marion [VerfasserIn]   i
Titel:Clonotypic CD20+ and CD19+ B cells in peripheral blood of patients with multiple myeloma post high-dose therapy and peripheral blood stem cell transplantation
Verf.angabe:Christof Rottenburger, Katja Kiel, Tobias Bösing, Friedrich W. Cremer, Gerhard Moldenhauer, Anthony D. Ho, Hartmut Goldschmidt and Marion Moos
E-Jahr:1999
Jahr:[August 1999]
Umfang:8 S.
Fussnoten:Elektronische Reproduktion der Druckausgabe ; Die Pluszeichen im Titel sind hochgestellt ; Gesehen am 10.12.2021
Titel Quelle:Enthalten in: British journal of haematology
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1955
Jahr Quelle:1999
Band/Heft Quelle:106(1999), 2, Seite 545-552
ISSN Quelle:1365-2141
Abstract:The number of circulating clonotypic B cells in patients with multiple myeloma (MM) after high-dose therapy (HDT) with peripheral blood stem cell transplantation (PBSCT) was investigated. Peripheral CD19+ B cells have been reported to persist throughout conventional and HDT and might resemble a source of relapse in patients with MM. We assessed the proportion of malignant cells in CD20+ and CD19+ cell fractions of 14 peripheral blood (PB) samples from 12 patients after HDT and PBSCT. Nine samples were obtained from patients in continuous remission, and five patients were in progressive disease or beginning relapse. The CD20+ fractions obtained had a mean purity of 96.8%. The percentages of tumour cells were determined using a quantitative allele-specific oligonucleotide PCR assay based on the method of limiting dilutions. In the group of patients in continuous remission the median number of tumour cells in the CD20+ cell fractions was 1.9/ml (range 0-7.2 tumour cells/ml PB) higher than in the CD20− fractions (median 0; range 0-29 tumour cells/ml PB). Higher tumour cell numbers in both fractions, particularly pronounced in the negative ones, were found in patients with progressive disease or beginning relapse (CD20+: range 3.8-585; median 32 tumour cells/ml PB; CD20−: range 25-25527; median 334 tumour cells/ml PB). Enrichment with the anti-CD19 antibody as a second pan B-cell marker revealed comparable tumour cell numbers. In conclusion, an anti-CD20 antibody treatment could be a promising approach for the eradication of malignant cells in the PB of patients in continuous remission after HDT and PBSCT with low amounts of tumour cells in the B-cell compartment and an almost complete absence of tumour cells in the CD20− fractions.
DOI:doi:10.1046/j.1365-2141.1999.01548.x
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Volltext ; Verlag: https://doi.org/10.1046/j.1365-2141.1999.01548.x
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2141.1999.01548.x
 DOI: https://doi.org/10.1046/j.1365-2141.1999.01548.x
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:anti-CD20 antibody treatment
 clonotypic B cells
 high-dose therapy
 multiple myeloma
 residual disease
K10plus-PPN:1780957262
Verknüpfungen:→ Zeitschrift

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