| Online-Ressource |
Verfasst von: | Radovits, Tamás [VerfasserIn]  |
| Oláh, Attila [VerfasserIn]  |
| Lux, Árpád [VerfasserIn]  |
| Németh, Balázs Tamás [VerfasserIn]  |
| Hidi, László [VerfasserIn]  |
| Birtalan, Ede [VerfasserIn]  |
| Kellermayer, Dalma [VerfasserIn]  |
| Mátyás, Csaba [VerfasserIn]  |
| Szabó, Gábor [VerfasserIn]  |
| Merkely, Béla [VerfasserIn]  |
Titel: | Rat model of exercise-induced cardiac hypertrophy |
Titelzusatz: | hemodynamic characterization using left ventricular pressure-volume analysis |
Verf.angabe: | Tamás Radovits, Attila Oláh, Árpád Lux, Balázs Tamás Németh, László Hidi, Ede Birtalan, Dalma Kellermayer, Csaba Mátyás, Gábor Szabó, and Béla Merkely |
E-Jahr: | 2013 |
Jahr: | 1 July 2013 |
Umfang: | 11 S. |
Fussnoten: | Gesehen am 13.12.2021 |
Titel Quelle: | Enthalten in: American journal of physiology / Heart and circulatory physiology |
Ort Quelle: | Bethesda, Md. : American Physiological Society, 1977 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 305(2013), 1 vom: Juli, Seite H124-H134 |
ISSN Quelle: | 1522-1539 |
Abstract: | Long-term exercise training is associated with characteristic structural and functional changes of the myocardium, termed athlete's heart. Several research groups investigated exercise training-induced left ventricular (LV) hypertrophy in animal models; however, only sporadic data exist about detailed hemodynamics. We aimed to provide functional characterization of exercise-induced cardiac hypertrophy in a rat model using the in vivo method of LV pressure-volume (P-V) analysis. After inducing LV hypertrophy by swim training, we assessed LV morphometry by echocardiography and performed LV P-V analysis using a pressure-conductance microcatheter to investigate in vivo cardiac function. Echocardiography showed LV hypertrophy (LV mass index: 2.41 ± 0.09 vs. 2.03 ± 0.08 g/kg, P < 0.01), which was confirmed by heart weight data and histomorphometry. Invasive hemodynamic measurements showed unaltered heart rate, arterial pressure, and LV end-diastolic volume along with decreased LV end-systolic volume, thus increased stroke volume and ejection fraction (73.7 ± 0.8 vs. 64.1 ± 1.5%, P < 0.01) in trained versus untrained control rats. The P-V loop-derived sensitive, load-independent contractility indexes, such as slope of end-systolic P-V relationship or preload recruitable stroke work (77.0 ± 6.8 vs. 54.3 ± 4.8 mmHg, P = 0.01) were found to be significantly increased. The observed improvement of ventriculoarterial coupling (0.37 ± 0.02 vs. 0.65 ± 0.08, P < 0.01), along with increased LV stroke work and mechanical efficiency, reflects improved mechanoenergetics of exercise-induced cardiac hypertrophy. Despite the significant hypertrophy, we observed unaltered LV stiffness (slope of end-diastolic P-V relationship: 0.043 ± 0.007 vs. 0.040 ± 0.006 mmHg/μl) and improved LV active relaxation (τ: 10.1 ± 0.6 vs. 11.9 ± 0.2 ms, P < 0.01). According to our knowledge, this is the first study that provides characterization of functional changes and hemodynamic relations in exercise-induced cardiac hypertrophy. |
DOI: | doi:10.1152/ajpheart.00108.2013 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1152/ajpheart.00108.2013 |
| Volltext: https://journals.physiology.org/doi/full/10.1152/ajpheart.00108.2013 |
| DOI: https://doi.org/10.1152/ajpheart.00108.2013 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | cardiac mechanoenergetics |
| diastolic function |
| exercise-induced cardiac hypertrophy |
| pressure-volume analysis |
| systolic function |
K10plus-PPN: | 1782007121 |
Verknüpfungen: | → Zeitschrift |
Rat model of exercise-induced cardiac hypertrophy / Radovits, Tamás [VerfasserIn]; 1 July 2013 (Online-Ressource)