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Verfasst von:Radovits, Tamás [VerfasserIn]   i
 Oláh, Attila [VerfasserIn]   i
 Lux, Árpád [VerfasserIn]   i
 Németh, Balázs Tamás [VerfasserIn]   i
 Hidi, László [VerfasserIn]   i
 Birtalan, Ede [VerfasserIn]   i
 Kellermayer, Dalma [VerfasserIn]   i
 Mátyás, Csaba [VerfasserIn]   i
 Szabó, Gábor [VerfasserIn]   i
 Merkely, Béla [VerfasserIn]   i
Titel:Rat model of exercise-induced cardiac hypertrophy
Titelzusatz:hemodynamic characterization using left ventricular pressure-volume analysis
Verf.angabe:Tamás Radovits, Attila Oláh, Árpád Lux, Balázs Tamás Németh, László Hidi, Ede Birtalan, Dalma Kellermayer, Csaba Mátyás, Gábor Szabó, and Béla Merkely
E-Jahr:2013
Jahr:1 July 2013
Umfang:11 S.
Fussnoten:Gesehen am 13.12.2021
Titel Quelle:Enthalten in: American journal of physiology / Heart and circulatory physiology
Ort Quelle:Bethesda, Md. : American Physiological Society, 1977
Jahr Quelle:2013
Band/Heft Quelle:305(2013), 1 vom: Juli, Seite H124-H134
ISSN Quelle:1522-1539
Abstract:Long-term exercise training is associated with characteristic structural and functional changes of the myocardium, termed athlete's heart. Several research groups investigated exercise training-induced left ventricular (LV) hypertrophy in animal models; however, only sporadic data exist about detailed hemodynamics. We aimed to provide functional characterization of exercise-induced cardiac hypertrophy in a rat model using the in vivo method of LV pressure-volume (P-V) analysis. After inducing LV hypertrophy by swim training, we assessed LV morphometry by echocardiography and performed LV P-V analysis using a pressure-conductance microcatheter to investigate in vivo cardiac function. Echocardiography showed LV hypertrophy (LV mass index: 2.41 ± 0.09 vs. 2.03 ± 0.08 g/kg, P < 0.01), which was confirmed by heart weight data and histomorphometry. Invasive hemodynamic measurements showed unaltered heart rate, arterial pressure, and LV end-diastolic volume along with decreased LV end-systolic volume, thus increased stroke volume and ejection fraction (73.7 ± 0.8 vs. 64.1 ± 1.5%, P < 0.01) in trained versus untrained control rats. The P-V loop-derived sensitive, load-independent contractility indexes, such as slope of end-systolic P-V relationship or preload recruitable stroke work (77.0 ± 6.8 vs. 54.3 ± 4.8 mmHg, P = 0.01) were found to be significantly increased. The observed improvement of ventriculoarterial coupling (0.37 ± 0.02 vs. 0.65 ± 0.08, P < 0.01), along with increased LV stroke work and mechanical efficiency, reflects improved mechanoenergetics of exercise-induced cardiac hypertrophy. Despite the significant hypertrophy, we observed unaltered LV stiffness (slope of end-diastolic P-V relationship: 0.043 ± 0.007 vs. 0.040 ± 0.006 mmHg/μl) and improved LV active relaxation (τ: 10.1 ± 0.6 vs. 11.9 ± 0.2 ms, P < 0.01). According to our knowledge, this is the first study that provides characterization of functional changes and hemodynamic relations in exercise-induced cardiac hypertrophy.
DOI:doi:10.1152/ajpheart.00108.2013
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1152/ajpheart.00108.2013
 Volltext: https://journals.physiology.org/doi/full/10.1152/ajpheart.00108.2013
 DOI: https://doi.org/10.1152/ajpheart.00108.2013
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cardiac mechanoenergetics
 diastolic function
 exercise-induced cardiac hypertrophy
 pressure-volume analysis
 systolic function
K10plus-PPN:1782007121
Verknüpfungen:→ Zeitschrift

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