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Verfasst von:Rühle, Alexander [VerfasserIn]   i
 Dai, Ping [VerfasserIn]   i
 Lopez Perez, Ramon [VerfasserIn]   i
 Strack, Maren [VerfasserIn]   i
 Brons, Stephan [VerfasserIn]   i
 Yijia, Qin [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Wuchter, Patrick [VerfasserIn]   i
 Grosu, Anca-Ligia [VerfasserIn]   i
 Huber, Peter E. [VerfasserIn]   i
 Nicolay, Nils [VerfasserIn]   i
Titel:Human mesenchymal stromal cells maintain their stem cell traits after high-LET particle irradiation - Potential implications for particle radiotherapy and manned space missions
Verf.angabe:Alexander Rühle, Dai Ping, Ramon Lopez Perez, Maren Strack, Stephan Brons, Qin Yijia, Jürgen Debus, Patrick Wuchter, Anca-Ligia Grosu, Peter E. Huber, Nils H. Nicolay
Jahr:2022
Umfang:10 S.
Fussnoten:Available online 21 October 2021 ; Gesehen am 13.12.2021
Titel Quelle:Enthalten in: Cancer letters
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1975
Jahr Quelle:2022
Band/Heft Quelle:524(2022), Seite 172-181
ISSN Quelle:1872-7980
Abstract:The influence of high-linear energy transfer (LET) particle radiation on the functionalities of mesenchymal stromal cells (MSCs) is largely unknown. Here, we analyzed the effects of proton (1H), helium (4He), carbon (12C) and oxygen (16O) ions on human bone marrow-MSCs. Cell cycle distribution and apoptosis induction were examined by flow cytometry, and DNA damage was quantified using γH2AX immunofluorescence and Western blots. Relative biological effectiveness values of MSCs amounted to 1.0-1.1 for 1H, 1.7-2.3 for 4He, 2.9-3.4 for 12C and 2.6-3.3 for 16O. Particle radiation did not alter the MSCs’ characteristic surface marker pattern, and MSCs maintained their multi-lineage differentiation capabilities. Apoptosis rates ranged low for all radiation modalities. At 24 h after irradiation, particle radiation-induced ATM and CHK2 phosphorylation as well as γH2AX foci numbers returned to baseline levels. The resistance of human MSCs to high-LET irradiation suggests that MSCs remain functional after exposure to moderate doses of particle radiation as seen in normal tissues after particle radiotherapy or during manned space flights. In the future, in vivo models focusing on long-term consequences of particle irradiation on the bone marrow niche and MSCs are needed.
DOI:doi:10.1016/j.canlet.2021.10.015
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.canlet.2021.10.015
 Volltext: https://www.sciencedirect.com/science/article/pii/S0304383521005255
 DOI: https://doi.org/10.1016/j.canlet.2021.10.015
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Carbon ions
 Helium ions
 High-LET radiation
 Mesenchymal stem cells
 Oxygen ions
 Particle radiotherapy
 Proton radiotherapy
 Radiotherapy
 Space radiation
K10plus-PPN:1782015345
Verknüpfungen:→ Zeitschrift

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