Standort: ---
Exemplare:
---
| Online-Ressource |
Verfasst von: | Gold, Annika [VerfasserIn]  |
| Tönshoff, Burkhard [VerfasserIn]  |
| Döhler, Bernd [VerfasserIn]  |
| Süsal, Caner [VerfasserIn]  |
Titel: | Association of graft survival with tacrolimus exposure and late intra-patient tacrolimus variability in pediatric and young adult renal transplant recipients |
Titelzusatz: | an international CTS registry analysis |
Verf.angabe: | Annika Gold, Burkhard Tönshoff, Bernd Döhler & Caner Süsal |
Jahr: | 2020 |
Umfang: | 12 S. |
Fussnoten: | First published: 02 September 2020 ; Gesehen am 13.12.2021 |
Titel Quelle: | Enthalten in: Transplant international |
Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1988 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 33(2020), 12, Seite 1681-1692 |
ISSN Quelle: | 1432-2277 |
Abstract: | Adolescent and young adult age is a high-risk window with an alarmingly increased likelihood of premature kidney graft loss due to immunological rejection. Using the large database of the Collaborative Transplant Study, we analyzed whether a more intense and less variable exposure to tacrolimus could counteract this young age-related enhanced immunoreactivity. Kidney graft recipients aged 12-23 years (n = 964) with a 1-year tacrolimus trough level between 4.0 and 10.9 ng/ml had a 5-year graft survival rate of 85.1%, significantly better than the poor 66.1% rate in patients with a trough level below 4.0 ng/ml who showed a 2.38-fold increased risk of graft loss in the multivariable analysis (P < 0.001). This association was not apparent in young children aged 0-11 years (n = 455) and less pronounced in adults aged 24-34 years (n = 1466). However, an intra-patient variability of tacrolimus (IPV) trough level ≥1.5 at post-transplant years 1 and 2 was associated with an increased graft loss risk in both 12- to 23-year-old and 0- to 11-year-old recipients (P < 0.001 and P = 0.045). Patients with high IPV made up as many as 30% of kidney graft recipients, indicating that a more intense and less variable exposure to tacrolimus could improve graft survival strongly in this high-risk group. |
DOI: | doi:10.1111/tri.13726 |
URL: | kostenfrei: Volltext ; Verlag: https://doi.org/10.1111/tri.13726 |
| kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.13726 |
| DOI: https://doi.org/10.1111/tri.13726 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | late intra-patient tacrolimus variability |
| pediatrics |
| renal allograft survival |
| tacrolimus exposure |
| young adults |
K10plus-PPN: | 1782039678 |
Verknüpfungen: | → Zeitschrift |
|
|
| |
Lokale URL UB: | Zum Volltext |
Association of graft survival with tacrolimus exposure and late intra-patient tacrolimus variability in pediatric and young adult renal transplant recipients / Gold, Annika [VerfasserIn]; 2020 (Online-Ressource)
68819339