| Online-Ressource |
Verfasst von: | Ramantani, Georgia [VerfasserIn]  |
| Kadish, Navah [VerfasserIn]  |
| Brandt, Armin [VerfasserIn]  |
| Strobl, Karl [VerfasserIn]  |
| Stathi, Angeliki [VerfasserIn]  |
| Wiegand, Gert [VerfasserIn]  |
| Schubert-Bast, Susanne [VerfasserIn]  |
| Mayer, Hans [VerfasserIn]  |
| Wagner, Kathrin [VerfasserIn]  |
| Korinthenberg, Rudolf [VerfasserIn]  |
| Stephani, Ulrich [VerfasserIn]  |
| van Velthoven, Vera [VerfasserIn]  |
| Zentner, Josef [VerfasserIn]  |
| Schulze-Bonhage, Andreas [VerfasserIn]  |
| Bast, Thomas [VerfasserIn]  |
Titel: | Seizure control and developmental trajectories after hemispherotomy for refractory epilepsy in childhood and adolescence |
Verf.angabe: | Georgia Ramantani, Navah Ester Kadish, Armin Brandt, Karl Strobl, Angeliki Stathi, Gert Wiegand, Susanne Schubert-Bast, Hans Mayer, Kathrin Wagner, Rudolf Korinthenberg, Ulrich Stephani, Vera van Velthoven, Josef Zentner, Andreas Schulze-Bonhage, and Thomas Bast |
E-Jahr: | 2013 |
Jahr: | March 18, 2013 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 14.12.2021 |
Titel Quelle: | Enthalten in: Epilepsia |
Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1909 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 54(2013), 6, Seite 1046-1055 |
ISSN Quelle: | 1528-1167 |
Abstract: | Purpose To evaluate the seizure control and developmental outcomes after hemispherotomy for refractory epilepsy in childhood and to identify their predictive factors. Methods We retrospectively studied the clinical courses and outcomes of 52 children with refractory epilepsy who underwent hemispherotomy in the Epilepsy Center Freiburg between 2002 and 2011. Key Findings Mean age at epilepsy onset was 1.8 years (range 0-8 years) and mean age at surgery was 6.7 years (range 6 months-18 years). The underlying etiology was congenital in 22 (42%) children, acquired in 24 (46%), and progressive in 6 (12%). At final follow-up of 1-9.8 years (mean 3.3), 43 children (83%) were seizure-free. Seizure outcome was not correlated to etiology, with the exception of hemimegalencephaly that was linked to poor seizure control. Presurgical development was impaired in all but one child. Postsurgical development highly correlated with presurgical development. Patients with acquired or progressive etiology, later epilepsy onset, and subsequent later surgery exhibited higher presurgical developmental status that substantially determined postoperative developmental outcome. Improved postsurgical development was determined by acquired etiology and seizure freedom off antiepileptic drugs. Significance In our study, most of the selected children and adolescents achieved seizure freedom, including those with congenital etiology. Developmental outcomes, however, were superior in patients with acquired etiology and older age at surgery, underscoring that it is never too late to reap the benefits of this procedure in terms of both epilepsy and development. |
DOI: | doi:10.1111/epi.12140 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/epi.12140 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.12140 |
| DOI: https://doi.org/10.1111/epi.12140 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Cognitive |
| Development |
| Epilepsy surgery |
| FCD |
| Hemimegalencephaly |
| Infarction |
| Outcomes |
| Rasmussen |
K10plus-PPN: | 1782067310 |
Verknüpfungen: | → Zeitschrift |
Seizure control and developmental trajectories after hemispherotomy for refractory epilepsy in childhood and adolescence / Ramantani, Georgia [VerfasserIn]; March 18, 2013 (Online-Ressource)