EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit

• Verfasst von: Plaschke, Konstanze [VerfasserIn]
• Verfasst von: Hill, Holger [VerfasserIn]
• Verfasst von: Engelhardt, Ria [VerfasserIn]
• Verfasst von: Thomas, C. [VerfasserIn]
• Verfasst von: Haken, Rebecca von [VerfasserIn]
• Verfasst von: Scholz, Mirijam Friderike [VerfasserIn]
• Verfasst von: Kopitz, Jürgen [VerfasserIn]
• Verfasst von: Bardenheuer, Hubert J. [VerfasserIn]
• Verfasst von: Weisbrod, Matthias [VerfasserIn]
• Verfasst von: Weigand, Markus A. [VerfasserIn]
• Titel: EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit
• Verf.angabe: K. Plaschke, H. Hill, R. Engelhardt, C. Thomas, R. Von Haken, M. Scholz, J. Kopitz, H.J. Bardenheuer, M. Weisbrod, M.A. Weigand
• E-Jahr: 2007
• Jahr: 05 November 2007
• Umfang: 7 S.
• Fussnoten: Gesehen am 14.12.2021
• Titel Quelle: Enthalten in: Anaesthesia
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1946
• Jahr Quelle: 2007
• Band/Heft Quelle: 62(2007), 12, Seite 1217-1223
• ISSN Quelle: 1365-2044
• DOI: doi:10.1111/j.1365-2044.2007.05255.x
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1782119892

Abstract

The aim of this study was to examine whether serum anticholinergic activity (SAA) is a reliable indicator of delirium in the ICU, and whether there is a significant correlation between SAA and quantitative electroencephalographic (EEG) data in delirious patients. In a prospective cohort study, we assessed ICU patients diagnosed with delirium (n = 37). EEG measurements and blood analysis including SAA were performed 48 h following ICU admission. The presence of delirium was evaluated using the Confusion Assessment Method for critically ill patients in ICU (CAM-ICU). The SAA level was measured using a competitive radioreceptor binding assay for muscarinergic receptors and quantitative EEG was measured using the CATEEM® system. We found that, under comparable conditions, patients in the delirium group showed a higher relative EEG theta power and a reduced alpha power (n = 17) than did the non-delirious patients (n = 20). No difference in measured SAA levels were seen; therefore, there was no correlation between SAA and EEG measurements in delirious patients. We conclude that, in contrast to the EEG, the SAA level cannot be proposed as a tool for diagnosing delirium in ICU patients.