Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Krämer, Alwin [VerfasserIn]   i
 Schultheis, Beate [VerfasserIn]   i
 Bergmann, J. [VerfasserIn]   i
 Willer, Andreas [VerfasserIn]   i
 Hegenbart, Ute [VerfasserIn]   i
 Ho, Anthony Dick [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Hehlmann, Rüdiger [VerfasserIn]   i
Titel:Alterations of the cyclin D1/pRb/p16INK4A pathway in multiple myeloma
Verf.angabe:A. Krämer, B. Schultheis, J. Bergmann, A. Willer, U. Hegenbart, A.D. Ho, H. Goldschmidt and R. Hehlmann
E-Jahr:2002
Jahr:30 August 2002
Umfang:8 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 14.12.2021 ; INK4A im Titel ist hochgestellt
Titel Quelle:Enthalten in: Leukemia
Ort Quelle:London : Springer Nature, 1997
Jahr Quelle:2002
Band/Heft Quelle:16(2002), 9, Seite 1844-1851
ISSN Quelle:1476-5551
Abstract:The retinoblastoma protein (pRb), p16INK4A, D-type cyclins, and their partners cyclin-dependent kinase (CDK) 4 and 6 constitute a G1 regulatory pathway commonly targeted in tumorigenesis. Several malignancies show a reciprocal correlation between genetic alterations of single members of the pRb pathway. Therefore, we determined the frequency of Rb deletions and cyclin D1 alterations by fluorescence in situ hybridization as well as 5′ CpG island hypermethylation of the p16INK4Agene using methylation-specific polymerase chain reaction in bone marrow mononuclear cells from 82 individuals with plasma cell disorders. Alterations in at least one of the components of the pathway were found in 75%. Cyclin D1 translocations or amplifications were detected in 14/82 (17.1%), Rb deletions at 13q14 in 23/82 (28%) of the cases, including three (3.6%) homozygous deletions. p16INK4A was hypermethylated in 33/57 (57.9%) of the samples. Further analysis revealed a highly significant correlation between cyclin D1 alterations and extramedullar or leukemic myeloma manifestations (P = 0.014; Fisher's test). Whereas Rb deletions seemed to occur alternatively to cyclin D1 alterations, no reciprocal correlation was found between p16INK4A hypermethylations and cyclin D1 or Rb locus aberrations. Cyclin D1 locus alterations and Rb deletions were associated with a significantly worse prognosis whereas p16INK4A hypermethylation had no impact on survival. We conclude that cyclin D1 and Rb aberrations seem to occur as alternative events in plasma cell malignancies and contribute to clinical course and prognosis. In contrast, although p16INK4A hypermethylation is frequent, inactivation of p16INK4A seems not to be involved in the pathogenesis of plasma cell disorders.
DOI:doi:10.1038/sj.leu.2402609
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1038/sj.leu.2402609
 Volltext: https://www.nature.com/articles/2402609
 DOI: https://doi.org/10.1038/sj.leu.2402609
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cancer Research
 general
 Hematology
 Intensive / Critical Care Medicine
 Internal Medicine
 Medicine/Public Health
 Oncology
K10plus-PPN:1782124403
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68822942   QR-Code
zum Seitenanfang