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Verfasst von:Krämer, Alwin [VerfasserIn]   i
 Neben, Kai [VerfasserIn]   i
 Ho, Anthony Dick [VerfasserIn]   i
Titel:Centrosome replication, genomic instability and cancer
Verf.angabe:A. Krämer, K. Neben and A.D. Ho (Medizinische Klinik und Poliklinik V, Ruprecht-Karls-Universität, Heidelberg, Germany)
E-Jahr:2002
Jahr:02 May 2002
Umfang:9 S.
Fussnoten:Gesehen am 14.12.2021
Titel Quelle:Enthalten in: Leukemia
Ort Quelle:London : Springer Nature, 1997
Jahr Quelle:2002
Band/Heft Quelle:16(2002), 5, Seite 767-775
ISSN Quelle:1476-5551
Abstract:Karyotypic alterations, including whole chromosome loss or gain, ploidy changes, and a variety of chromosome aberrations are common in cancer cells. If proliferating cells fail to coordinate centrosome duplication with DNA replication, this will inevitably lead to a change in ploidy, and the formation of monopolar or multipolar spindles will generally provoke abnormal segregation of chromosomes. Indeed, it has long been recognized that errors in the centrosome duplication cycle may be an important cause of aneuploidy and thus contribute to cancer formation. This view has recently received fresh impetus with the description of supernumerary centrosomes in almost all solid human tumors. As the primary microtubule organizing center of most eukaryotic cells, the centrosome assures symmetry and bipolarity of the cell division process, a function that is essential for accurate chromosome segregation. In addition, a growing body of evidence indicates that centrosomes might be imortant for initiating S phase and completing cytokinesis. Centrosomes undergo duplication precisely once before cell division. Recent reports have revealed that this process is linked to the cell division cycle via cyclin-dependent kinase (cdk) 2 activity that couples centriole duplication to the onset of DNA replication at the G1/S phase transition. Alterations in G1/S phase regulating proteins like the retinoblastoma protein, cyclins D and E, cdk4 and 6, cdk inhibitors p16INK4A and p15INK4B, and p53 are among the most frequent aberrations observed in human malignancies. These alterations might not only lead to unrestrained proliferation, but also cause karyotypic instability by uncontrolled centrosome replication. Since several excellent reports on cell cycle regulation and cancer have been published, this review will focus on the role of centrosomes in cell cycle progression, as well as causes and consequences of aberrant centrosome replication in human neoplasias.
DOI:doi:10.1038/sj.leu.2402454
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1038/sj.leu.2402454
 Volltext: https://www.nature.com/articles/2402454
 DOI: https://doi.org/10.1038/sj.leu.2402454
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cancer Research
 general
 Hematology
 Intensive / Critical Care Medicine
 Internal Medicine
 Medicine/Public Health
 Oncology
K10plus-PPN:1782127453
Verknüpfungen:→ Zeitschrift

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