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| Verfasst von: | Neben, Kai [VerfasserIn]  |
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| | Möhler, Thomas [VerfasserIn] |
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| | Krämer, Alwin [VerfasserIn] |
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| | Benner, Axel [VerfasserIn] |
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| | Egerer, Gerlinde [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| Titel: | Response to thalidomide in progressive multiple myeloma is not mediated by inhibition of angiogenic cytokine secretion |
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| Verf.angabe: | Kai Neben, Thomas Moehler, Alwin Kraemer, Axel Benner, Gerlinde Egerer, Anthony D. Ho and Hartmut Goldschmidt |
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| E-Jahr: | 2001 |
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| Jahr: | 20 December 2001 |
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| Umfang: | 4 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Gesehen am 14.12.2021 |
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| Titel Quelle: | Enthalten in: British journal of haematology |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1955 |
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| Jahr Quelle: | 2001 |
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| Band/Heft Quelle: | 115(2001), 3, Seite 605-608 |
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| ISSN Quelle: | 1365-2141 |
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| Abstract: | Thalidomide (Thal) is a drug with anti-angiogenic properties. To explore whether the effect of Thal on angiogenesis is associated with a reduction of angiogenic cytokine levels in progressive multiple myeloma (MM), plasma levels of basic fibroblast growth factor, vascular endothelial growth factor, interleukin 6, tumour necrosis factor-α and hepatocyte growth factor (HGF) were measured in 51 patients at 0, 3 and 6 months of Thal therapy. After 6 months of treatment, 26 patients were considered to be responsive to Thal therapy, including 17 minimal responses, eight partial responses and one complete response. Only HGF (decreasing, P = 0·02) in the group of responsive patients showed a statistically significant change over a period of 6 months. Because HGF levels are known to correlate to MM tumour burden, we conclude that the mechanism of action of Thal in MM is not caused by a specific inhibition of angiogenic cytokine secretion. |
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| DOI: | doi:10.1046/j.1365-2141.2001.03142.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1046/j.1365-2141.2001.03142.x |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2141.2001.03142.x |
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| | DOI: https://doi.org/10.1046/j.1365-2141.2001.03142.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | angiogenesis |
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| | basic fibroblast growth factor |
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| | multiple myeloma |
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| | thalidomide |
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| | vascular endothelial growth factor |
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| K10plus-PPN: | 1782133739 |
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| Verknüpfungen: | → Zeitschrift |
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Response to thalidomide in progressive multiple myeloma is not mediated by inhibition of angiogenic cytokine secretion / Neben, Kai [VerfasserIn]; 20 December 2001 (Online-Ressource)
