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Verfasst von:Bai, Liping [VerfasserIn]   i
 Pfeifer, Tobias [VerfasserIn]   i
 Gross, Wolfgang [VerfasserIn]   i
 Torre, Carolina de la [VerfasserIn]   i
 Zhao, Shuyang [VerfasserIn]   i
 Liu, Li [VerfasserIn]   i
 Schäfer, Michael [VerfasserIn]   i
 Herr, Ingrid [VerfasserIn]   i
Titel:Establishment of tumor treating fields combined with mild hyperthermia as novel supporting therapy for pancreatic cancer
Verf.angabe:Liping Bai, Tobias Pfeifer, Wolfgang Gross, Carolina De La Torre, Shuyang Zhao, Li Liu, Michael Schaefer and Ingrid Herr
E-Jahr:2021
Jahr:03 November 2021
Umfang:17 S.
Fussnoten:Gesehen am 15.12.2021
Titel Quelle:Enthalten in: Frontiers in oncology
Ort Quelle:Lausanne : Frontiers Media, 2011
Jahr Quelle:2021
Band/Heft Quelle:11(2021) vom: 3. Nov., Artikel-ID 738801, Seite 1-17
ISSN Quelle:2234-943X
Abstract:Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with poor prognosis and limited therapeutic options. Alternating electrical fields with low intensity called "Tumor Treating Fields" (TTFields) are a new, non-invasive approach with almost no side effects and phase 3 trials are ongoing in advanced PDAC. We evaluated TTFields in combination with mild hyperthermia. Three established human PDAC cell lines and an immortalized pancreatic duct cell line were treated with TTFields and hyperthermia at 38.5°C, followed by microscopy, assays for MTT, migration, colony and sphere formation, RT-qPCR, FACS, Western blot, microarray and bioinformatics, and in silico analysis using the online databases GSEA, KEGG, Cytoscape-String, and Kaplan-Meier Plotter. Whereas TTFields and hyperthermia alone had weak effects, their combination strongly inhibited the viability of malignant, but not those of nonmalignant cells. Progression features and the cell cycle were impaired, and autophagy was induced. The identified target genes were key players in autophagy, the cell cycle and DNA repair. The expression profiles of part of these target genes were significantly involved in the survival of PDAC patients. In conclusion, the combination of TTFields with mild hyperthermia results in greater efficacy without increased toxicity and could be easily clinically approved as supporting therapy.
DOI:doi:10.3389/fonc.2021.738801
URL:kostenfrei: Volltext: https://doi.org/10.3389/fonc.2021.738801
 kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fonc.2021.738801/full
 DOI: https://doi.org/10.3389/fonc.2021.738801
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Errata: Bai, Liping, 1977 - : Corrigendum
 Errata: Bai, Liping, 1977 - : Corrigendum: Establishment of tumor treating fields combined with mild hyperthermia as novel supporting therapy for pancreatic cancer
K10plus-PPN:1782251626
Verknüpfungen:→ Zeitschrift
 
 
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