Stroke seasonality associations with subtype, etiology and laboratory results in the Ludwigshafen Stroke Study (LuSSt)

• Verfasst von: Palm, Frederick [VerfasserIn]
• Verfasst von: Martins dos Santos, Michael [VerfasserIn]
• Verfasst von: Urbanek, Christian [VerfasserIn]
• Verfasst von: Greulich, Matthias [VerfasserIn]
• Verfasst von: Zimmer, Kathrin [VerfasserIn]
• Verfasst von: Safer, Anton [VerfasserIn]
• Verfasst von: Grau, Armin J. [VerfasserIn]
• Verfasst von: Becher, Heiko [VerfasserIn]
• Titel: Stroke seasonality associations with subtype, etiology and laboratory results in the Ludwigshafen Stroke Study (LuSSt)
• Verf.angabe: Frederick Palm, Michael Dos Santos, Christian Urbanek, Matthias Greulich, Kathrin Zimmer, Anton Safer, Armin Jürgen Grau, Heiko Becher
• E-Jahr: 2013
• Jahr: 6 February 2013
• Umfang: 9 S.
• Fussnoten: Gesehen am 16.12.2021
• Titel Quelle: Enthalten in: European journal of epidemiology
• Ort Quelle: [Cham] : Springer Nature Switzerland AG, 1985
• Jahr Quelle: 2013
• Band/Heft Quelle: 28(2013), 5, Seite 373-381
• ISSN Quelle: 1573-7284
• DOI: doi:10.1007/s10654-013-9772-4
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1782347445

Abstract

Data on seasonal differences in stroke incidence are conflicting. Little is known about seasonal variability in etiological stroke subtypes and population-based data on possible trigger factors are lacking. The Ludwigshafen Stroke Study is a prospective population-based stroke registry. All residents of the city of Ludwigshafen who suffer from acute stroke or TIA are registered. Patients with first-ever stroke (FES) were included for the present analysis. Between January 1, 2006 and December 31st, 2010, 1,779 patients (age 71.7 ± 13.4 years (mean + standard deviation; 897 (50.4 %) women) suffered a FES. Incidence for FES was lowest in summer (reference) with significantly higher rates in winter (rate ratio (RR) 1.20, 95 % confidence interval (CI) 1.05-1.37) and spring (RR 1.21 95 % CI 1.06-1.38). First-ever ischemic stroke (FEIS) was more common in winter (RR 1.16, 95 %CI 1.01-1.34) and first-ever intracerebral haemorrhage (FE-ICH) was more frequent in spring (RR 2.0, 95 %CI 1.24-3.22) than in summer. In FES, systolic and diastolic blood pressure on admission (SBP/DBP) showed significant variation with lowest values in summer (SBP: p = 0.02; DBP p = 0.05). In subtypes of FEIS, cardioembolism tended to be more common in winter (p = 0.14). There were no differences in risk factor prevalence between seasons. Leukocyte count on admission was lowest in summer (8.2 ± 1.4/μl) and highest in winter (8.9 ± 1.9/μl; p = 0.008). The hematocrit showed a similar trend (p = 0.06). Our data show higher incidence rates for FES in winter and spring, for FEIS in winter and for FE-ICH in spring. Variations in blood pressure on admission and leukocyte counts were associated with these findings and may possibly contribute to seasonal stroke variability.