The pre- and postoperative prevalence and risk factors of ASA nonresponse in vascular surgery

• Verfasst von: Kazimi, Alia Uzra [VerfasserIn]
• Verfasst von: Weber, Christian Friedrich [VerfasserIn]
• Verfasst von: Keese, Michael [VerfasserIn]
• Verfasst von: Miesbach, Wolfgang [VerfasserIn]
• Titel: The pre- and postoperative prevalence and risk factors of ASA nonresponse in vascular surgery
• Verf.angabe: Alia Uzra Kazimi, MD, Christian Friedrich Weber, MD, Michael Keese, MD, and Wolfgang Miesbach, MD
• E-Jahr: 2021
• Jahr: October 5, 2021
• Umfang: 7 S.
• Fussnoten: Gesehen am 16.12.2021
• Titel Quelle: Enthalten in: Clinical and applied thrombosis, hemostasis
• Ort Quelle: Thousand Oaks, Calif. : Sage, 1995
• Jahr Quelle: 2021
• Band/Heft Quelle: 27(2021), Artikel-ID 10760296211044723, Seite 1-7
• ISSN Quelle: 1938-2723
• DOI: doi:10.1177/10760296211044723
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ASA nonresponse
• Sach-SW: Multiplate Analyzer
• Sach-SW: platelet aggregation
• Sach-SW: vascular surgery
• K10plus-PPN: 1782393560

Abstract

BackgroundAn antiplatelet therapy with acetylsalicylic acid (ASA) is prescribed in the prevention of cardiovascular events, but around 24% of ASA takers are resistant to the treatment.AimIn this prospective, observational cohort study, we aimed to identify the prevalence and risk factors of ASA nonresponse in patients who underwent vascular surgery.MethodsThe study was conducted in the University hospital in Frankfurt am Main. In total, 70 patients were pre-treated with 100?mg of ASA per day and underwent either elective carotid thromboendarterectomy, femoral thromboendarterectomy or endovascular aneurysm repair of the abdominal aorta. The platelet function was measured on the first preoperative and the second or fourth postoperative day with the multiple electrode aggregometry by in-vitro stimulation with arachidonic acid (ASPItest) and thrombin receptor activating peptide 6 (TRAPtest). The primary end point was the in-vitro induced platelet aggregation in the ASPItest. If the ASPItest amounted ≥400 AU???min, the patients were categorized as ASA nonresponders.ResultsThe total prevalence of ASA nonresponse in our study was 20% preoperatively and 35.7% postoperatively (p?=?0.005). As significant predictors for ASA nonresponse, we demonstrated the area under the aggregation curve in the TRAPtest preoperatively (p?=?0.04) and postoperatively (p?=?0.02), and the two comorbidities arterial hypertension (P?