Navigation überspringen
Universitätsbibliothek Heidelberg
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Lissek, Thomas [VerfasserIn]   i
 Andrianarivelo, Andry [VerfasserIn]   i
 Saint-Jour, Estefani [VerfasserIn]   i
 Allichon, Marie-Charlotte [VerfasserIn]   i
 Bauersachs, Hanke [VerfasserIn]   i
 Nassar, Merie [VerfasserIn]   i
 Piette, Charlotte [VerfasserIn]   i
 Pruunsild, Priit [VerfasserIn]   i
 Tan, Yan-Wei [VerfasserIn]   i
 Forget, Benoit [VerfasserIn]   i
 Heck, Nicolas [VerfasserIn]   i
 Caboche, Jocelyne [VerfasserIn]   i
 Venance, Laurent [VerfasserIn]   i
 Vanhoutte, Peter [VerfasserIn]   i
 Bading, Hilmar [VerfasserIn]   i
Titel:Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion
Verf.angabe:Thomas Lissek, Andry Andrianarivelo, Estefani Saint-Jour, Marie-Charlotte Allichon, Hanke Gwendolyn Bauersachs, Merie Nassar, Charlotte Piette, Priit Pruunsild, Yan-Wei Tan, Benoit Forget, Nicolas Heck, Jocelyne Caboche, Laurent Venance, Peter Vanhoutte and Hilmar Bading
E-Jahr:2021
Jahr:18 October 2021
Umfang:16 S.
Fussnoten:Gesehen am 17.12.2021
Titel Quelle:Enthalten in: European Molecular Biology OrganizationEMBO reports
Ort Quelle:[London] : Nature Publishing Group UK, 2000
Jahr Quelle:2021
Band/Heft Quelle:22(2021), 12 vom: Dez., Artikel-ID e51882, Seite 1-16
ISSN Quelle:1469-3178
Abstract:We show here that the transcription factor Npas4 is an important regulator of medium spiny neuron spine density and electrophysiological parameters and that it determines the magnitude of cocaine-induced hyperlocomotion in mice. Npas4 is induced by synaptic stimuli that cause calcium influx, but not dopaminergic or PKA-stimulating input, in mouse medium spiny neurons and human iPSC-derived forebrain organoids. This induction is independent of ubiquitous kinase pathways such as PKA and MAPK cascades, and instead depends on calcineurin and nuclear calcium signalling. Npas4 controls a large regulon containing transcripts for synaptic molecules, such as NMDA receptors and VDCC subunits, and determines in vivo MSN spine density, firing rate, I/O gain function and paired-pulse facilitation. These functions at the molecular and cellular levels control the locomotor response to drugs of abuse, as Npas4 knockdown in the nucleus accumbens decreases hyperlocomotion in response to cocaine in male mice while leaving basal locomotor behaviour unchanged.
DOI:doi:10.15252/embr.202051882
URL:kostenfrei: Volltext: https://doi.org/10.15252/embr.202051882
 kostenfrei: Volltext: https://www.embopress.org/doi/full/10.15252/embr.202051882
 DOI: https://doi.org/10.15252/embr.202051882
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:addiction
 calcium
 cocaine
 locomotion
 Npas4
K10plus-PPN:1782420436
Verknüpfungen:→ Zeitschrift
 
 
Lokale URL UB: Zum Volltext

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68833467   QR-Code
zum Seitenanfang