A man with hereditary exostoses and high-grade non-Hodgkin's lymphoma of the bone

• Verfasst von: Neben, Kai [VerfasserIn]
• Verfasst von: Werner, M. [VerfasserIn]
• Verfasst von: Bernd, Ludger [VerfasserIn]
• Verfasst von: Ewerbeck, Volker [VerfasserIn]
• Verfasst von: Delling, G. [VerfasserIn]
• Verfasst von: Ho, Anthony Dick [VerfasserIn]
• Titel: A man with hereditary exostoses and high-grade non-Hodgkin's lymphoma of the bone
• Verf.angabe: K. Neben, M. Werner, L. Bernd, V. Ewerbeck, G. Delling, A. Ho
• E-Jahr: 2001
• Jahr: 3 October 2001
• Umfang: 3 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 21.12.2021
• Titel Quelle: Enthalten in: Annals of hematology
• Ort Quelle: Berlin : Springer, 1955
• Jahr Quelle: 2001
• Band/Heft Quelle: 80(2001), 11, Seite 682-684
• ISSN Quelle: 1432-0584
• DOI: doi:10.1007/s002770100379
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1782638199

Abstract

Multiple cartilaginous exostoses (MCE) is an autosomal dominant disorder that can lead to malignant transformation from exostoses to a secondary chondrosarcoma. We present a case report of a 52-year-old man with MCE who had a palpable mass at the left shoulder. At the site of the left proximal humerus, a cartilaginous exostosis was localized, suggesting that the tumor developed by a malignant transformation of an exostosis into a secondary chondrosarcoma. Interestingly, a biopsy showed a diffuse large B-cell lymphoma with Burkitt-like features. To our knowledge, the association of high-grade lymphoma and hereditary exostoses has not been described previously. This case demonstrates that a malignant tumor at the location of a cartilaginous exostosis is not necessarily a chondrosarcoma and that a biopsy is an essential part of the diagnostic work-up.