Progress in defining the mechanism of action of antidepressants

• Verfasst von: Schwaninger, Markus [VerfasserIn]
• Verfasst von: Weisbrod, Matthias [VerfasserIn]
• Verfasst von: Knepel, Willhart [VerfasserIn]
• Titel: Progress in defining the mechanism of action of antidepressants
• Verf.angabe: Markus Schwaninger, Matthias Weisbrod, Willhart Knepel
• Jahr: 1997
• Umfang: 7 S.
• Fussnoten: Elektronische Reproduktion der Druck-Ausgabe 18. November 2012 ; Gesehen am 23.12.2021
• Titel Quelle: Enthalten in: CNS drugs
• Ort Quelle: Berlin [u.a.] : Springer, 1994
• Jahr Quelle: 1997
• Band/Heft Quelle: 8(1997), 3, Seite 237-243
• ISSN Quelle: 1179-1934
• DOI: doi:10.2165/00023210-199708030-00006
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1783547715

Abstract

The mechanism of action of antidepressants is still unknown. The delayed onset of their therapeutic effect suggests that they act through an adaptive process. Recent research has demonstrated that neural plasticity and learning, which may underlie the induction of depression by repetitive psychosocial stress. involve gene transcription through the cyclic adenosine monophosphate (CAMP)— and calcium-responsive element (CRE) and its cognate transcription factor CREB. By downregulating β-adrenergic receptors linked to CAMP-formation and serotonin 5-HT2 receptors linked to intracellular calcium mobilisation and blocking voltage-dependent calcium channels, antidepressants can inhibit gene transcription through the CRE. Thus, modification of CRE-directed transcription may contribute to the therapeutic efficacy of antidepressants.