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| Verfasst von: | Schütz, Aline [VerfasserIn]  |
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| | Richter, Christin [VerfasserIn] |
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| | Weissgerber, Petra [VerfasserIn] |
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| | Tsvilovskyy, Volodymyr [VerfasserIn] |
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| | Hesse, Michael [VerfasserIn] |
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| | Ottenheijm, Roger [VerfasserIn] |
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| | Zimmermann, Frank [VerfasserIn] |
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| | Buchholz, Stefanie [VerfasserIn] |
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| | Medert, Rebekka [VerfasserIn] |
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| | Dlugosz, Sascha [VerfasserIn] |
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| | Kuryshev, Vladimir [VerfasserIn] |
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| | Benes, Vladimir [VerfasserIn] |
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| | Flockerzi, Veit [VerfasserIn] |
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| | Fleischmann, Bernd K. [VerfasserIn] |
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| | Cavalié, Adolfo [VerfasserIn] |
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| | Freichel, Marc [VerfasserIn] |
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| Titel: | Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos |
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| Verf.angabe: | Aline Schütz, Christin Richter, Petra Weissgerber, Volodymyr Tsvilovskyy, Michael Hesse, Roger Ottenheijm, Frank Zimmermann, Stefanie Buchholz, Rebekka Medert, Sascha Dlugosz, Vladimir Kuryshev, Vladimir Benes, Veit Flockerzi, Bernd K. Fleischmann, Adolfo Cavalié, and Marc Freichel |
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| E-Jahr: | 2021 |
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| Jahr: | October 19, 2021 |
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| Umfang: | 19 S. |
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| Fussnoten: | Gesehen am 24.12.2021 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 37(2021), 3, Artikel-ID 109851, Seite 1-13, e1-e6 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Early embryogenesis depends on proper control of intracellular homeostasis of ions including Ca2+ and Mg2+. Deletion of the Ca2+ and Mg2+ conducting the TRPM7 channel is embryonically lethal in mice but leaves compaction, blastomere polarization, blastocoel formation, and correct specification of the lineages of the trophectoderm and inner cell mass unaltered despite that free cytoplasmic Ca2+ and Mg2+ is reduced at the two-cell stage. Although Trpm7−/− embryos are able to hatch from the zona pellucida, no expansion of Trpm7−/− trophoblast cells can be observed, and Trpm7−/− embryos are not identifiable in utero at E6.5 or later. Given the proliferation and adhesion defect of Trpm7−/− trophoblast stem cells and the ability of Trpm7−/− ESCs to develop to embryos in tetraploid embryo complementation assays, we postulate a critical role of TRPM7 in trophectoderm cells and their failure during implantation as the most likely explanation of the developmental arrest of Trpm7-deficient mouse embryos. |
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| DOI: | doi:10.1016/j.celrep.2021.109851 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.celrep.2021.109851 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124721013188 |
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| | DOI: https://doi.org/10.1016/j.celrep.2021.109851 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | calcium |
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| | developmental failure |
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| | embryo implantation |
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| | embryonic lethality |
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| | embryonic stem cells |
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| | magnesium |
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| | trophectoderm |
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| | TRPM7 |
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| K10plus-PPN: | 1783564601 |
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| Verknüpfungen: | → Zeitschrift |
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Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos / Schütz, Aline [VerfasserIn]; October 19, 2021 (Online-Ressource)
