| |  Online-Ressource |
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| Verfasst von: | Zhang, Xiaolong [VerfasserIn]  |
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| | Braun, Urs [VerfasserIn] |
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| | Harneit, Anais [VerfasserIn] |
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| | Zang, Zhenxiang [VerfasserIn] |
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| | Geiger-Primo, Lena S. [VerfasserIn] |
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| | Betzel, Richard F. [VerfasserIn] |
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| | Chen, Junfang [VerfasserIn] |
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| | Schweiger, Janina [VerfasserIn] |
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| | Schwarz, Kristina [VerfasserIn] |
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| | Reinwald, Jonathan Rochus [VerfasserIn] |
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| | Fritze, Stefan [VerfasserIn] |
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| | Witt, Stephanie [VerfasserIn] |
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| | Rietschel, Marcella [VerfasserIn] |
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| | Nöthen, Markus Maria [VerfasserIn] |
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| | Degenhardt, Franziska [VerfasserIn] |
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| | Schwarz, Emanuel [VerfasserIn] |
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| | Hirjak, Dusan [VerfasserIn] |
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| | Meyer-Lindenberg, Andreas [VerfasserIn] |
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| | Bassett, Danielle S. [VerfasserIn] |
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| | Tost, Heike [VerfasserIn] |
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| Titel: | Generative network models of altered structural brain connectivity in schizophrenia |
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| Verf.angabe: | Xiaolong Zhang, Urs Braun, Anais Harneit, Zhenxiang Zang, Lena S. Geiger, Richard F. Betzel, Junfang Chen, Janina I. Schweiger, Kristina Schwarz, Jonathan Rochus Reinwald, Stefan Fritze, Stephanie Witt, Marcella Rietschel, Markus M. Nöthen, Franziska Degenhardt, Emanuel Schwarz, Dusan Hirjak, Andreas Meyer-Lindenberg, Danielle S. Bassett, Heike Tost |
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| E-Jahr: | 2021 |
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| Jahr: | 15 January 2021 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 12.04.2021 |
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| Titel Quelle: | Enthalten in: NeuroImage |
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| Ort Quelle: | Orlando, Fla. : Academic Press, 1992 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 225(2021), Artikel-ID 117510, Seite 1-10 |
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| ISSN Quelle: | 1095-9572 |
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| Abstract: | Alterations in the structural connectome of schizophrenia patients have been widely characterized, but the mechanisms remain largely unknown. Generative network models have recently been introduced as a tool to test the biological underpinnings of altered brain network formation. We evaluated different generative network models in healthy controls (n=152), schizophrenia patients (n=66), and their unaffected first-degree relatives (n=32), and we identified spatial and topological factors contributing to network formation. We further investigated how these factors relate to cognition and to polygenic risk for schizophrenia. Our data show that among the four tested classes of generative network models, structural brain networks were optimally accounted for by a two-factor model combining spatial constraints and topological neighborhood structure. The same wiring model explained brain network formation across study groups. However, relatives and schizophrenia patients exhibited significantly lower spatial constraints and lower topological facilitation compared to healthy controls. Further exploratory analyses point to potential associations of the model parameter reflecting spatial constraints with the polygenic risk for schizophrenia and cognitive performance. Our results identify spatial constraints and local topological structure as two interrelated mechanisms contributing to regular brain network formation as well as altered connectomes in schizophrenia and healthy individuals at familial risk for schizophrenia. On an exploratory level, our data further point to the potential relevance of spatial constraints for the genetic risk for schizophrenia and general cognitive functioning, thereby encouraging future studies in following up on these observations to gain further insights into the biological basis and behavioral relevance of model parameters. |
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| DOI: | doi:10.1016/j.neuroimage.2020.117510 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neuroimage.2020.117510 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1053811920309952 |
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| | DOI: https://doi.org/10.1016/j.neuroimage.2020.117510 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cognition |
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| | Generative network models |
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| | Intermediate phenotype |
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| | Polygenetic risk |
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| | Structural connectivity |
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| K10plus-PPN: | 175365758X |
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| Verknüpfungen: | → Zeitschrift |
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Generative network models of altered structural brain connectivity in schizophrenia / Zhang, Xiaolong [VerfasserIn]; 15 January 2021 (Online-Ressource)
