| |  Online-Ressource |
|---|
| Verfasst von: | Angeles, Arlou Kristina J. [VerfasserIn]  |
|---|
| | Janke, Florian [VerfasserIn] |
|---|
| | Bauer, Simone [VerfasserIn] |
|---|
| | Christopoulos, Petros [VerfasserIn] |
|---|
| | Riediger, Anja Lisa [VerfasserIn] |
|---|
| | Sültmann, Holger [VerfasserIn] |
|---|
| Titel: | Liquid biopsies beyond mutation calling |
|---|
| Titelzusatz: | genomic and epenomic features of cell-free DNA in cancer |
|---|
| Verf.angabe: | Arlou Kristina Angeles, Florian Janke, Simone Bauer, Petros Christopoulos, Anja Lisa Riediger and Holger Sültmann |
|---|
| E-Jahr: | 2021 |
|---|
| Jahr: | 10 November 2021 |
|---|
| Umfang: | 20 S. |
|---|
| Fussnoten: | Gesehen am 05.01.2022 |
|---|
| Titel Quelle: | Enthalten in: Cancers |
|---|
| Ort Quelle: | Basel : MDPI, 2009 |
|---|
| Jahr Quelle: | 2021 |
|---|
| Band/Heft Quelle: | 13(2021), 22, Artikel-ID 5615, Seite 1-20 |
|---|
| ISSN Quelle: | 2072-6694 |
|---|
| Abstract: | Cell-free DNA (cfDNA) analysis using liquid biopsies is a non-invasive method to gain insights into the biology, therapy response, mechanisms of acquired resistance and therapy escape of various tumors. While it is well established that individual cancer treatment options can be adjusted by panel next-generation sequencing (NGS)-based evaluation of driver mutations in cfDNA, emerging research additionally explores the value of deep characterization of tumor cfDNA genomics and fragmentomics as well as nucleosome modifications (chromatin structure), and methylation patterns (epigenomics) for comprehensive and multi-modal assessment of cfDNA. These tools have the potential to improve disease monitoring, increase the sensitivity of minimal residual disease identification, and detection of cancers at earlier stages. Recent progress in emerging technologies of cfDNA analysis is summarized, the added potential clinical value is highlighted, strengths and limitations are identified and compared with conventional targeted NGS analysis, and current challenges and future directions are discussed. |
|---|
| DOI: | doi:10.3390/cancers13225615 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/cancers13225615 |
|---|
| | Volltext: https://www.mdpi.com/2072-6694/13/22/5615 |
|---|
| | DOI: https://doi.org/10.3390/cancers13225615 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | cell-free DNA |
|---|
| | DNA hydroxymethylation |
|---|
| | DNA methylation |
|---|
| | epigenomics |
|---|
| | fragmentomics |
|---|
| | histone modification |
|---|
| | liquid biopsy |
|---|
| | nucleosome positioning |
|---|
| | precision medicine |
|---|
| K10plus-PPN: | 1784834998 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Liquid biopsies beyond mutation calling / Angeles, Arlou Kristina J. [VerfasserIn]; 10 November 2021 (Online-Ressource)
