Diagnostic tests for the detection of human papillomavirus-associated cervical lesions

• Verfasst von: Reuschenbach, Miriam [VerfasserIn]
• Verfasst von: Knebel Doeberitz, Magnus von [VerfasserIn]
• Titel: Diagnostic tests for the detection of human papillomavirus-associated cervical lesions
• Verf.angabe: Miriam Reuschenbach and Magnus von Knebel Doeberitz
• Jahr: 2013
• Umfang: 13 S.
• Fussnoten: Gesehen am 10.01.2022
• Titel Quelle: Enthalten in: Current pharmaceutical design
• Ort Quelle: Hilversum : Bentham Science Publ., 2000
• Jahr Quelle: 2013
• Band/Heft Quelle: 19(2013), 8, Seite 1358-1370
• ISSN Quelle: 1873-4286
• DOI: doi:10.2174/1381612811319080002
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Alphapapillomavirus
• Sach-SW: Chromosomal Instability
• Sach-SW: DNA Methylation
• Sach-SW: DNA, Viral
• Sach-SW: Female
• Sach-SW: Humans
• Sach-SW: Reproducibility of Results
• Sach-SW: S Phase
• Sach-SW: Uterine Cervical Neoplasms
• Sach-SW: Vaginal Smears
• K10plus-PPN: 1785254790

Abstract

Current diagnostic approaches for primary cervical cancer screening, work-up of equivocal or positive screening results or follow- - up after treatment of precancerous lesions primarily rely on the morphologic interpretation of squamous epithelial cells (Pap cytology), - in some setting accompanied by the detection of human papillomavirus DNA and have largely contributed to remarkable reduction - of disease incidence in countries with implemented screening programs. However, these approaches are limited by a poor sensitivity and - reproducibility of Pap cytology and low specificity for high grade cervical intraepithelial neoplasia of HPV DNA detection assays. Early - detection might be improved by complementing or even replacing these tests by markers which are more directly related to molecular - events triggering HPV-induced carcinogenesis and thereby might deliver more accurate diagnostic performance. The delineation of molecular - changes which occur during different stages of HPV infections and the identification of changes which induce neoplastic alterations - allow for the detection of markers that specifically highlight the transforming stage of the infection where viral oncogenes are overexpressed - and therefore allow for a more specific diagnosis of lesions that require treatment. The evaluation of such markers in clinical - studies revealed that some indeed show an improved diagnostic performance compared to Pap cytology or HPV DNA tests only.