Comparison of different lymphoma cell purging modalities

• Verfasst von: Hundsdörfer, Patrick [VerfasserIn]
• Verfasst von: Frühauf, Stefan [VerfasserIn]
• Verfasst von: Haberkorn, M. [VerfasserIn]
• Verfasst von: Höft, Raimund [VerfasserIn]
• Verfasst von: Haas, Rainer [VerfasserIn]
• Verfasst von: Zeller, W. Jens [VerfasserIn]
• Titel: Comparison of different lymphoma cell purging modalities
• Titelzusatz: an experimental study with K422 lymphoma cells
• Verf.angabe: P. Hundsdörfer, S. Fruehauf, M. Haberkorn, R. Höft, R. Haas, W. J. Zeller
• E-Jahr: 1999
• Jahr: July 22, 1999
• Umfang: 8 S.
• Fussnoten: Gesehen am 12.01.2022
• Titel Quelle: Enthalten in: Acta haematologica
• Ort Quelle: Basel : Karger, 1948
• Jahr Quelle: 1999
• Band/Heft Quelle: 101(1999), 4, Seite 185-192
• ISSN Quelle: 1421-9662
• DOI: doi:10.1159/000040951
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1785806181

Abstract

Blood-derived autografts from patients with non-Hodgkin’s lymphoma (NHL) are frequently contaminated with clonogenic lymphoma cells. In order to obtain a more efficient lymphoma cell depletion from the transplants we compared the efficiency of different purging techniques: B-cell-directed depletion, CD34+ selection by immunomagnetic beads (IMB selection) or by immunoadsorption with a biotin-avidin column (BAC selection). Furthermore, two combination approaches were investigated: IMB selection after B-cell depletion as well as BAC selection after B-cell depletion.