Heart transplantation under coumarin therapy

• Verfasst von: Karck, Matthias [VerfasserIn]
• Verfasst von: Haverich, Axel [VerfasserIn]
• Titel: Heart transplantation under coumarin therapy
• Titelzusatz: friend or foe?
• Verf.angabe: M. Karck, A. Haverich
• E-Jahr: 1994
• Jahr: Nov 1994
• Umfang: 5 S.
• Fussnoten: Gesehen am 12.01.2022
• Titel Quelle: Enthalten in: European journal of anaesthesiology
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1996
• Jahr Quelle: 1994
• Band/Heft Quelle: 11(1994), 6, Seite 475-479
• ISSN Quelle: 1365-2346
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adult
• Sach-SW: Aged
• Sach-SW: Blood Loss, Surgical
• Sach-SW: Blood Transfusion
• Sach-SW: Blood Transfusion, Autologous
• Sach-SW: Chest Tubes
• Sach-SW: Coronary Artery Bypass
• Sach-SW: Female
• Sach-SW: Heart Transplantation
• Sach-SW: Hemostasis, Surgical
• Sach-SW: Heparin
• Sach-SW: Humans
• Sach-SW: Injections, Intravenous
• Sach-SW: Male
• Sach-SW: Middle Aged
• Sach-SW: Partial Thromboplastin Time
• Sach-SW: Phenprocoumon
• Sach-SW: Prothrombin
• Sach-SW: Retrospective Studies
• Sach-SW: Vitamin K
• Sach-SW: Whole Blood Coagulation Time
• K10plus-PPN: 1785855573

Abstract

Thirty-six patients were included in a retrospective study of the effect of pre-operative anticoagulant therapy on peri-operative blood loss and haemostatic changes after heart transplantation. Eleven patients (group H) had received intravenous heparin for at least 3 weeks before cardiac transplantation. Twelve patients (group P) had been transplanted when fully anticoagulated with phenprocoumon. A control group of 13 patients (group C) had undergone bypass grafting of their coronary arteries with no pre-operative anticoagulant therapy. Post-operative drainage from the chest drains was 700 ml (median) in group H, 425 ml in group P, and 360 ml in group C (group H vs. group C: P < 0.05). After heparinization for cardiopulmonary bypass, activated clotting time was 462 s (median) in group H, 1500 s in group P, and 727 s in group C (P < 0.003 vs. groups H and P). Post-operatively, patients in group P were given more units of fresh frozen plasma (median 2.5 units; P < 0.01), prothrombin complex concentrate (median 1000 I.U.; P < 0.05) and vitamin K (median 10 mg; P < 0.05) than groups H and C. Heart transplantation under full phenprocoumon therapy does not increase the likelihood of complications caused by peri-operative bleeding.