| |  Online-Ressource |
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| Verfasst von: | Caers, Jo [VerfasserIn]  |
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| | Hose, Dirk [VerfasserIn] |
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| | Kuipers, Ine [VerfasserIn] |
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| | Bos, Tomas Jan [VerfasserIn] |
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| | Van Valckenborgh, Els [VerfasserIn] |
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| | Menu, Eline [VerfasserIn] |
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| | De Bruyne, Elke [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| | Van Camp, Ben [VerfasserIn] |
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| | Klein, Bernard [VerfasserIn] |
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| | Vanderkerken, Karin [VerfasserIn] |
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| Titel: | Thymosin β4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma |
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| Verf.angabe: | Jo Caers, Dirk Hose, Ine Kuipers, Tomas Jan Bos, Els Van Valckenborgh, Eline Menu, Elke De Bruyne, Hartmut Goldschmidt, Ben Van Camp, Bernard Klein, Karin Vanderkerken |
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| E-Jahr: | 2010 |
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| Jahr: | [2010] |
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| Jahr des Originals: | 2009 |
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| Umfang: | 5 S. |
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| Fussnoten: | Published online 2009 Oct 14 ; Gesehen am 12.01.2022 |
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| Titel Quelle: | Enthalten in: Haematologica, the hematology journal |
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| Ort Quelle: | Pavia : Ferrata Storti Foundation, 2005 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 95(2010), 1, Seite 163-167 |
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| ISSN Quelle: | 1592-8721 |
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| Abstract: | Thymosin β4 (Tβ4) is a polypeptide involved in cellular proliferation, differentiation, and migration, over-expressed in several tumor entities. We evaluated its expression and function in 298 newly diagnosed multiple myeloma patients and the murine 5TMM model. Mean Tβ4 expression was significantly lower in myeloma cells compared to normal plasma cells (P<0.001). The same observation can be made in the 5TMM-mouse model by qRT-PCR and ELISA. Here, Tβ4 overexpression by lentiviral transduction of 5T33MMvt-cells led to significantly decreased proliferative and migratory capacities and increased sensitivity to apoptosis-induction. Mice injected with Tβ4 over-expressing myeloma cells showed a longer survival compared to mice injected with controls (88,9 vs. 65,9 days, P<0.05). In 209 MM patients treated with high-dose therapy and autologous stem cell transplantation, expression of Tβ4 below the median was associated with a significantly shorter event free survival (37.6 vs. 26.2 months, P<0.05). In conclusion, our results indicate a possible tumor suppressive function of Tβ4. |
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| DOI: | doi:10.3324/haematol.2009.006411 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag ; Resolving-System: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805724/ |
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| | Volltext: https://doi.org/10.3324/haematol.2009.006411 |
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| | DOI: https://doi.org/10.3324/haematol.2009.006411 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1785858297 |
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| Verknüpfungen: | → Zeitschrift |
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Thymosin β4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma / Caers, Jo [VerfasserIn]; [2010] (Online-Ressource)
