| |  Online-Ressource |
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| Verfasst von: | Frühauf, Stefan [VerfasserIn]  |
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| | Veldwijk, Marlon Romano [VerfasserIn] |
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| | Seeger, Timon [VerfasserIn] |
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| | Schubert, Mario [VerfasserIn] |
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| | Maier-Laufs, Stephanie [VerfasserIn] |
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| | Topaly, Julian [VerfasserIn] |
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| | Wuchter, Patrick [VerfasserIn] |
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| | Dillmann, Falk [VerfasserIn] |
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| | Eckstein, Volker [VerfasserIn] |
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| | Wenz, Frederik [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Calandra, Gary [VerfasserIn] |
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| Titel: | A combination of granulocyte-colony-stimulating factor (G-CSF) and plerixafor mobilizes more primitive peripheral blood progenitor cells than G-CSF alone |
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| Titelzusatz: | results of a European phase II study |
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| Verf.angabe: | Stefan Fruehauf, Marlon Romano Veldwijk, Timon Seeger, Mario Schubert, Stephanie Laufs, Julian Topaly, Patrick Wuchter, Falk Dillmann, Volker Eckstein, Frederik Wenz, Hartmut Goldschmidt, Anthony Dick Ho and Gary Calandra |
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| E-Jahr: | 2009 |
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| Jahr: | [2009] |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 12.01.2022 |
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| Titel Quelle: | Enthalten in: Cytotherapy |
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| Ort Quelle: | New York, NY : Elsevier, 1999 |
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| Jahr Quelle: | 2009 |
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| Band/Heft Quelle: | 11(2009), 8, Seite 992-1001 |
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| ISSN Quelle: | 1477-2566 |
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| Abstract: | Background aims - Previous studies in xenograft models have shown that human peripheral blood progenitor cells (PBPC) mobilized with the CXCR4 antagonist plerixafor (AMD3100) have a higher bone marrow (BM) reconstitution potential than granulocyte-colony-stimulating factor (G-CSF)-mobilized PBPC. - Methods - PBPC obtained during G-CSF-supported mobilization before and after a supplementary administration of AMD3100 from patients with multiple myeloma and non-Hodgkin's lymphoma (n=15; phase II study) were investigated for co-expression of primitive and lineage-associated markers, their proliferative activity in vitro and repopulation potential after clinical transplantation. - Results - A significant increase in primitive CD34+ CD38− cells was observed in intraindividual comparisons of all patients after administration of G-CSF+AMD3100 (peripheral blood: median 8-fold, range 2,4-fold - 39-fold) compared with G-CSF alone. Using a long-term culture-initiating cell assay, this increase was confirmed. After transplantation of G-CSF+AMD3100-mobilized PBPC, the time to leukocyte reconstitution >1×103/μL and platelet reconstitution >2×104/μL was 14 (10-19 days) and 13 days (10-15 days), respectively. A complete and stable hematologic reconstitution (platelets >1.5×105/μL) was observed in 91% of all patients within 35 days. - Conclusions - An additional application of AMD3100 to a standard G-CSF mobilization regimen leads to a significant increase in primitive PBPC with high repopulation capacity. |
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| DOI: | doi:10.3109/14653240903121245 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3109/14653240903121245 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1465324909703470 |
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| | DOI: https://doi.org/10.3109/14653240903121245 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | AMD3100 |
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| | granulocyte-colony-stimulating factor |
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| | mobilization |
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| | peripheral blood progenitor cells |
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| K10plus-PPN: | 1785862588 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ combination of granulocyte-colony-stimulating factor (G-CSF) and plerixafor mobilizes more primitive peripheral blood progenitor cells than G-CSF alone / Frühauf, Stefan [VerfasserIn]; [2009] (Online-Ressource)
