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| Verfasst von: | Julián-Serrano, Sachelly [VerfasserIn]  |
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| | Yuan, Fangcheng [VerfasserIn] |
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| | Wheeler, William [VerfasserIn] |
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| | Benyamin, Beben [VerfasserIn] |
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| | Machiela, Mitchell J [VerfasserIn] |
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| | Arslan, Alan A [VerfasserIn] |
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| | Beane-Freeman, Laura E [VerfasserIn] |
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| | Bracci, Paige M [VerfasserIn] |
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| | Duell, Eric J [VerfasserIn] |
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| | Du, Mengmeng [VerfasserIn] |
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| | Gallinger, Steven [VerfasserIn] |
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| | Giles, Graham G [VerfasserIn] |
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| | Goodman, Phyllis J [VerfasserIn] |
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| | Kooperberg, Charles [VerfasserIn] |
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| | Marchand, Loic Le [VerfasserIn] |
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| | Neale, Rachel E [VerfasserIn] |
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| | Shu, Xiao-Ou [VerfasserIn] |
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| | Van Den Eeden, Stephen K [VerfasserIn] |
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| | Visvanathan, Kala [VerfasserIn] |
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| | Zheng, Wei [VerfasserIn] |
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| | Albanes, Demetrius [VerfasserIn] |
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| | Andreotti, Gabriella [VerfasserIn] |
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| | Ardanaz, Eva [VerfasserIn] |
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| | Babic, Ana [VerfasserIn] |
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| | Berndt, Sonja I [VerfasserIn] |
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| | Brais, Lauren K [VerfasserIn] |
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| | Brennan, Paul [VerfasserIn] |
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| | Bueno-de-Mesquita, Bas [VerfasserIn] |
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| | Buring, Julie E [VerfasserIn] |
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| | Chanock, Stephen J [VerfasserIn] |
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| | Childs, Erica J [VerfasserIn] |
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| | Chung, Charles C [VerfasserIn] |
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| | Fabiánová, Eleonora [VerfasserIn] |
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| | Foretová, Lenka [VerfasserIn] |
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| | Fuchs, Charles S [VerfasserIn] |
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| | Gaziano, J Michael [VerfasserIn] |
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| | Gentiluomo, Manuel [VerfasserIn] |
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| | Giovannucci, Edward L [VerfasserIn] |
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| | Goggins, Michael G [VerfasserIn] |
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| | Hackert, Thilo [VerfasserIn] |
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| | Hartge, Patricia [VerfasserIn] |
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| | Hassan, Manal M [VerfasserIn] |
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| | Holcátová, Ivana [VerfasserIn] |
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| | Holly, Elizabeth A [VerfasserIn] |
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| | Hung, Rayjean I [VerfasserIn] |
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| | Janout, Vladimir [VerfasserIn] |
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| | Kurtz, Robert C [VerfasserIn] |
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| | Lee, I-Min [VerfasserIn] |
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| | Malats, Núria [VerfasserIn] |
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| | McKean, David [VerfasserIn] |
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| | Milne, Roger L [VerfasserIn] |
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| | Newton, Christina C [VerfasserIn] |
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| | Oberg, Ann L [VerfasserIn] |
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| | Perdomo, Sandra [VerfasserIn] |
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| | Peters, Ulrike [VerfasserIn] |
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| | Porta, Miquel [VerfasserIn] |
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| | Rothman, Nathaniel [VerfasserIn] |
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| | Schulze, Matthias B [VerfasserIn] |
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| | Sesso, Howard D [VerfasserIn] |
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| | Silverman, Debra T [VerfasserIn] |
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| | Thompson, Ian M [VerfasserIn] |
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| | Wactawski-Wende, Jean [VerfasserIn] |
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| | Weiderpass, Elisabete [VerfasserIn] |
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| | Wenstzensen, Nicolas [VerfasserIn] |
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| | White, Emily [VerfasserIn] |
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| | Wilkens, Lynne R [VerfasserIn] |
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| | Yu, Herbert [VerfasserIn] |
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| | Zeleniuch-Jacquotte, Anne [VerfasserIn] |
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| | Zhong, Jun [VerfasserIn] |
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| | Kraft, Peter [VerfasserIn] |
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| | Li, Dounghui [VerfasserIn] |
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| | Campbell, Peter T [VerfasserIn] |
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| | Petersen, Gloria M [VerfasserIn] |
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| | Wolpin, Brian M [VerfasserIn] |
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| | Risch, Harvey A [VerfasserIn] |
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| | Amundadottir, Laufey T [VerfasserIn] |
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| | Klein, Alison P [VerfasserIn] |
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| | Yu, Kai [VerfasserIn] |
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| | Stolzenberg-Solomon, Rachael Z [VerfasserIn] |
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| Titel: | Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma |
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| Titelzusatz: | a pathway analysis of genome-wide association studies |
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| Verf.angabe: | Sachelly Julián-Serrano, Fangcheng Yuan, William Wheeler, Beben Benyamin, Mitchell J Machiela, Alan A Arslan, Laura E Beane-Freeman, Paige M Bracci, Eric J Duell, Mengmeng Du, Steven Gallinger, Graham G Giles, Phyllis J Goodman, Charles Kooperberg, Loic Le Marchand, Rachel E Neale, Xiao-Ou Shu, Stephen K Van Den Eeden, Kala Visvanathan, Wei Zheng, Demetrius Albanes, Gabriella Andreotti, Eva Ardanaz, Ana Babic, Sonja I Berndt, Lauren K Brais, Paul Brennan, Bas Bueno-de-Mesquita, Julie E Buring, Stephen J Chanock, Erica J Childs, Charles C Chung, Eleonora Fabiánová, Lenka Foretová, Charles S Fuchs, J Michael Gaziano, Manuel Gentiluomo, Edward L Giovannucci, Michael G Goggins, Thilo Hackert, Patricia Hartge, Manal M Hassan, Ivana Holcátová, Elizabeth A Holly, Rayjean I Hung, Vladimir Janout, Robert C Kurtz, I-Min Lee, Núria Malats, David McKean, Roger L Milne, Christina C Newton, Ann L Oberg, Sandra Perdomo, Ulrike Peters, Miquel Porta, Nathaniel Rothman, Matthias B Schulze, Howard D Sesso, Debra T Silverman, Ian M Thompson, Jean Wactawski-Wende, Elisabete Weiderpass, Nicolas Wenstzensen, Emily White, Lynne R Wilkens, Herbert Yu, Anne Zeleniuch-Jacquotte, Jun Zhong, Peter Kraft, Dounghui Li, Peter T Campbell, Gloria M Petersen, Brian M Wolpin, Harvey A Risch, Laufey T Amundadottir, Alison P Klein, Kai Yu, and Rachael Z Stolzenberg-Solomon |
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| E-Jahr: | 2021 |
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| Jahr: | 13 July 2021 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 17.01.2022 |
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| Titel Quelle: | Enthalten in: The American journal of clinical nutrition |
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| Ort Quelle: | Amsterdam : Elsevier, 1952 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 114(2021), 4, Seite 1408-1417 |
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| ISSN Quelle: | 1938-3207 |
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| | 1938-3215 |
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| Abstract: | Epidemiological studies have suggested positive associations for iron and red meat intake with risk of pancreatic ductal adenocarcinoma (PDAC). Inherited pathogenic variants in genes involved in the hepcidin-regulating iron metabolism pathway are known to cause iron overload and hemochromatosis.The objective of this study was to determine whether common genetic variation in the hepcidin-regulating iron metabolism pathway is associated with PDAC.We conducted a pathway analysis of the hepcidin-regulating genes using single nucleotide polymorphism (SNP) summary statistics generated from 4 genome-wide association studies in 2 large consortium studies using the summary data-based adaptive rank truncated product method. Our population consisted of 9253 PDAC cases and 12,525 controls of European descent. Our analysis included 11 hepcidin-regulating genes [bone morphogenetic protein 2 (BMP2), bone morphogenetic protein 6 (BMP6), ferritin heavy chain 1 (FTH1), ferritin light chain (FTL), hepcidin (HAMP), homeostatic iron regulator (HFE), hemojuvelin (HJV), nuclear factor erythroid 2-related factor 2 (NRF2), ferroportin 1 (SLC40A1), transferrin receptor 1 (TFR1), and transferrin receptor 2 (TFR2)] and their surrounding genomic regions (±20 kb) for a total of 412 SNPs.The hepcidin-regulating gene pathway was significantly associated with PDAC (P = 0.002), with the HJV, TFR2, TFR1, BMP6, and HAMP genes contributing the most to the association.Our results support that genetic susceptibility related to the hepcidin-regulating gene pathway is associated with PDAC risk and suggest a potential role of iron metabolism in pancreatic carcinogenesis. Further studies are needed to evaluate effect modification by intake of iron-rich foods on this association. |
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| DOI: | doi:10.1093/ajcn/nqab217 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/ajcn/nqab217 |
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| | DOI: https://doi.org/10.1093/ajcn/nqab217 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1786248352 |
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| Verknüpfungen: | → Zeitschrift |
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Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma / Julián-Serrano, Sachelly [VerfasserIn]; 13 July 2021 (Online-Ressource)
