Sampling the membrane

• Verfasst von: Lemberg, Marius [VerfasserIn]
• Titel: Sampling the membrane
• Titelzusatz: function of rhomboid-family proteins
• Verf.angabe: Marius K. Lemberg
• E-Jahr: 2013
• Jahr: 28 January 2013
• Umfang: 8 S.
• Fussnoten: Gesehen am 19.01.2022
• Titel Quelle: Enthalten in: Trends in cell biology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1991
• Jahr Quelle: 2013
• Band/Heft Quelle: 23(2013), 5 vom: Mai, Seite 210-217
• ISSN Quelle: 1879-3088
• DOI: doi:10.1016/j.tcb.2013.01.002
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: endoplasmic reticulum-associated protein degradation
• Sach-SW: pseudoenzyme
• Sach-SW: regulated intramembrane proteolysis
• Sach-SW: regulated protein trafficking
• K10plus-PPN: 1786460688

Abstract

Rhomboids constitute a conserved protein superfamily that specifically binds membrane proteins and directs them into various different cellular pathways ranging from regulated secretion to endoplasmic reticulum (ER)-associated degradation (ERAD). Rhomboid proteases are known to release protein domains from membranes by a cut in their membrane anchor, whereas an emerging new class of rhomboid-family proteins lacks key catalytic residues and is not proteolytically active. Recent work has shown that these rhomboid pseudoproteases, including iRhoms and derlins, bind membrane proteins to regulate their fate, but the underlying molecular mechanism is not known. This review summarizes recent advances in the molecular understanding of rhomboid-family proteins and discusses common principles in how they recognize and bind proteins in the plane of the membrane.