| Online-Ressource |
Verfasst von: | Roos-Weil, Damien [VerfasserIn]  |
| Dietrich, Sascha [VerfasserIn]  |
| Boumendil, Ariane [VerfasserIn]  |
| Polge, Emmanuelle [VerfasserIn]  |
| Bron, Dominique [VerfasserIn]  |
| Carreras, Enric [VerfasserIn]  |
| Iriondo Atienza, Arturo [VerfasserIn]  |
| Arcese, William [VerfasserIn]  |
| Beelen, Dietrich W. [VerfasserIn]  |
| Cornelissen, Jan J. [VerfasserIn]  |
| Kröger, Nicolaus [VerfasserIn]  |
| Milone, Giuseppe [VerfasserIn]  |
| Rossi, Giuseppe [VerfasserIn]  |
| Jardin, Fabrice [VerfasserIn]  |
| Peters, Christina [VerfasserIn]  |
| Rocha, Vanderson [VerfasserIn]  |
| Sureda, Anna [VerfasserIn]  |
| Mohty, Mohamad [VerfasserIn]  |
| Dreger, Peter [VerfasserIn]  |
Titel: | Stem cell transplantation can provide durable disease control in blastic plasmacytoid dendritic cell neoplasm |
Titelzusatz: | a retrospective study from the European Group for Blood and Marrow Transplantation |
Verf.angabe: | Damien Roos-Weil, Sascha Dietrich, Ariane Boumendil, Emmanuelle Polge, Dominique Bron, Enric Carreras, Arturo Iriondo Atienza, William Arcese, Dietrich W. Beelen, Jan J. Cornelissen, Nicolaus Kröger, Giuseppe Milone, Giuseppe Rossi, Fabrice Jardin, Christina Peters, Vanderson Rocha, Anna Sureda, Mohamad Mohty, and Peter Dreger, on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties |
Jahr: | 2013 |
Umfang: | 7 S. |
Fussnoten: | Prepublished online November 30, 2012 ; Gesehen am 19.01.2022 |
Titel Quelle: | Enthalten in: Blood |
Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 121(2013), 3 vom: 17. Jan., Seite 440-446 |
ISSN Quelle: | 1528-0020 |
Abstract: | Patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) have a poor prognosis with conventional chemotherapy. In the present study, we retrospectively analyzed the outcome of patients with BPDCN who underwent allogeneic stem cell transplantation (allo-SCT) or autologous stem cell transplantation (auto-SCT). A total of 39 patients (allo-SCT, n = 34; auto-SCT, n = 5) were identified in the European Group for Blood and Marrow Transplantation registry. The 34 allo-SCT patients had a median age of 41 years (range, 10-70) and received transplantations from sibling (n = 11) or unrelated donors (n = 23) between 2003 and 2009. MAC was used in 74% of patients. Nineteen allo-SCT patients (56%) received transplantations in first complete remission. The 3-year cumulative incidence of relapse, disease-free survival, and overall survival was 32%, 33%, and 41%, respectively. By univariate comparison, being in first remission at allo-SCT favorably influenced survival, whereas age, donor source, and chronic GVHD had no significant impact. We conclude that high-dose therapy followed by allo-SCT from related or unrelated donors can provide durable remission even in elderly patients with BPDCN. However, it remains to be shown if graft-versus-malignancy effects can contribute significantly to BPDCN control after allo-SCT. |
DOI: | doi:10.1182/blood-2012-08-448613 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1182/blood-2012-08-448613 |
| Volltext: https://ashpublications.org/blood/article/121/3/440/30983/Stem-cell-transplantation-can-provide-durable |
| DOI: https://doi.org/10.1182/blood-2012-08-448613 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1786473003 |
Verknüpfungen: | → Zeitschrift |
Stem cell transplantation can provide durable disease control in blastic plasmacytoid dendritic cell neoplasm / Roos-Weil, Damien [VerfasserIn]; 2013 (Online-Ressource)