Ocular axial length and diabetic retinopathy

• Verfasst von: Wang, Qian [VerfasserIn]
• Verfasst von: Wang, Ya Xing [VerfasserIn]
• Verfasst von: Wu, Shou Ling [VerfasserIn]
• Verfasst von: Chen, Shuo Hua [VerfasserIn]
• Verfasst von: Yan, Yan Ni [VerfasserIn]
• Verfasst von: Yang, Mo Chi [VerfasserIn]
• Verfasst von: Yang, Jing Yan [VerfasserIn]
• Verfasst von: Zhou, Wen Jia [VerfasserIn]
• Verfasst von: Chan, Szy Yann [VerfasserIn]
• Verfasst von: Zhang, Xiao Hui [VerfasserIn]
• Verfasst von: Yang, Xuan [VerfasserIn]
• Verfasst von: Lei, Ya Hui [VerfasserIn]
• Verfasst von: Qin, Shu Qi [VerfasserIn]
• Verfasst von: Chen, Meng Xi [VerfasserIn]
• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Verfasst von: Wei, Wen Bin [VerfasserIn]
• Titel: Ocular axial length and diabetic retinopathy
• Titelzusatz: the Kailuan Eye Study
• Verf.angabe: Qian Wang, Ya Xing Wang, Shou Ling Wu, Shuo Hua Chen, Yan Ni Yan, Mo Chi Yang, Jing Yan Yang, Wen Jia Zhou, Szy Yann Chan, Xiao Hui Zhang, Xuan Yang, Ya Hui Lei, Shu Qi Qin, Meng Xi Chen, Jost B. Jonas, and Wen Bin Wei
• E-Jahr: 2019
• Jahr: August 2019
• Umfang: 7 S.
• Fussnoten: Gesehen am 19.01.2022
• Titel Quelle: Enthalten in: Investigative ophthalmology & visual science
• Ort Quelle: Rockville, Md. : ARVO, 1977
• Jahr Quelle: 2019
• Band/Heft Quelle: 60(2019), 10, Seite 3689-3695
• ISSN Quelle: 1552-5783
• DOI: doi:10.1167/iovs.19-27531
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1786484897

Abstract

To examine the role of ocular axial length as an ocular parameter for the prevalence and severity of diabetic retinopathy (DR). The cross-sectional Kailuan Diabetic Retinopathy Study included patients with diabetes who participated in the community-based longitudinal Kailuan Study and who had undergone ocular fundus photography. The fundus photographs were graded using the Early Treatment of Diabetic Retinopathy Study criteria. The study included 1096 patients with diabetes (mean age: 60.8 ± 9.4 years; axial length: 23.37 ± 0.92 mm). In binary regression analysis, a higher DR prevalence was associated with shorter axial length (P = 0.007; odds ratio [OR]: 0.81; 95% confidence interval [CI]: 0.70, 0.95) after adjusting for longer known duration of diabetes (P = 0.02; OR: 1.13; 95%CI: 1.02, 1.24) and higher fasting blood glucose concentration (P < 0.001; OR: 1.38; 95%CI: 1.26, 1.52). A more severe DR stage was associated (regression coefficient r: 0.46) with shorter ocular axial length (P = 0.047; standardized regression coefficient β: −0.06) after adjusting for higher fasting blood glucose (P < 0.001; β: 0.41) and longer known duration of diabetes (P = 0.045; β: 0.07). Longer axial length was associated with a lower DR prevalence (P = 0.003; β: −0.10) after adjusting for younger age (P < 0.001), male sex (P < 0.001), higher body mass index (P = 0.016), and lower fasting blood glucose concentration (P = 0.036). After adjusting for systemic risk factors, DR prevalence decreased by 19% (95%CI: 5, 30) for each millimeter increase in axial length. With longer axial length being a surrogate for axial myopia, the marked increase in myopia prevalence worldwide may lead to a relative decrease in the prevalence and incidence of DR in future.