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Verfasst von:Baturina, Galina S. [VerfasserIn]   i
 Katkova, Liubov E. [VerfasserIn]   i
 Schmitt, Claus P. [VerfasserIn]   i
 Solenov, Evgeniy I. [VerfasserIn]   i
 Zarogiannis, Sotirios G. [VerfasserIn]   i
Titel:Comparison of isotonic activation of cell volume regulation in rat peritoneal mesothelial cells and in kidney outer medullary collecting duct principal cells
Verf.angabe:Galina S. Baturina, Liubov E. Katkova, Claus Peter Schmitt, Evgeniy I. Solenov and Sotirios G. Zarogiannis
E-Jahr:2021
Jahr:3 October 2021
Umfang:10 S.
Fussnoten:Gesehen am 20.01.2022
Titel Quelle:Enthalten in: Biomolecules
Ort Quelle:Basel : MDPI, 2011
Jahr Quelle:2021
Band/Heft Quelle:11(2021), 10, Artikel-ID 1452, Seite 1-10
ISSN Quelle:2218-273X
Abstract:In disease states, mesothelial cells are exposed to variable osmotic conditions, with high osmotic stress exerted by peritoneal dialysis (PD) fluids. They contain unphysiologically high concentrations of glucose and result in major peritoneal membrane transformation and PD function loss. The effects of isotonic entry of urea and myo-inositol in hypertonic (380 mOsm/kg) medium on the cell volume of primary cultures of rat peritoneal mesothelial cells and rat kidney outer medullary collecting duct (OMCD) principal cells were studied. In hypertonic medium, rat peritoneal mesothelial cells activated a different mechanism of cell volume regulation in the presence of isotonic urea (100 mM) in comparison to rat kidney OMCD principal cells. In kidney OMCD cells inflow of urea into the shrunken cell results in restoration of cell volume. In the shrunken peritoneal mesothelial cells, isotonic urea inflow caused a small volume increase and activated regulatory volume decrease (RVD). Isotonic myo-inositol activated RVD in hypertonic medium in both cell types. Isotonic application of both osmolytes caused a sharp increase of intracellular calcium both in peritoneal mesothelial cells and in kidney OMCD principal cells. In conclusion, peritoneal mesothelial cells exhibit RVD mechanisms when challenged with myo-inositol and urea under hyperosmolar isotonic switch from mannitol through involvement of calcium-dependent control. Myo-inositol effects were identical with the ones in OMCD principal cells whereas urea effects in OMCD principal cells led to no RVD induction.
DOI:doi:10.3390/biom11101452
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/biom11101452
 Volltext: https://www.mdpi.com/2218-273X/11/10/1452
 DOI: https://doi.org/10.3390/biom11101452
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cell volume regulation
 kidney principal cells
 mesothelial cells
 organic osmolytes
 osmotic stress
K10plus-PPN:1786604604
Verknüpfungen:→ Zeitschrift

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