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| Verfasst von: | Tian, Ming [VerfasserIn]  |
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| | Ticer, Taylor [VerfasserIn] |
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| | Wang, Qikun [VerfasserIn] |
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| | Walker, Sierra [VerfasserIn] |
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| | Pham, Anthony [VerfasserIn] |
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| | Suh, Annie [VerfasserIn] |
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| | Busatto, Sara [VerfasserIn] |
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| | Davidovich, Irina [VerfasserIn] |
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| | Al-Kharboosh, Rawan [VerfasserIn] |
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| | Lewis-Tuffin, Laura [VerfasserIn] |
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| | Ji, Baoan [VerfasserIn] |
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| | Quinones-Hinojosa, Alfredo [VerfasserIn] |
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| | Talmon, Yeshayahu [VerfasserIn] |
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| | Shapiro, Shane [VerfasserIn] |
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| | Rückert, Felix [VerfasserIn] |
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| | Wolfram, Joy [VerfasserIn] |
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| Titel: | Adipose-derived biogenic nanoparticles for suppression of inflammation |
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| Verf.angabe: | Ming Tian, Taylor Ticer, Qikun Wang, Sierra Walker, Anthony Pham, Annie Suh, Sara Busatto, Irina Davidovich, Rawan Al-Kharboosh, Laura Lewis-Tuffin, Baoan Ji, Alfredo Quinones-Hinojosa, Yeshayahu Talmon, Shane Shapiro, Felix Rückert, and Joy Wolfram |
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| Jahr: | 2020 |
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| Umfang: | 13 S. |
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| Fussnoten: | First published: 18 February 2020 ; Gesehen am 20.01.2022 |
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| Titel Quelle: | Enthalten in: Small |
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| Ort Quelle: | Weinheim : Wiley-VCH, 2005 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 16(2020), 10, Artikel-ID 1904064, Seite 1-13 |
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| ISSN Quelle: | 1613-6829 |
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| Abstract: | Extracellular vesicles secreted from adipose-derived mesenchymal stem cells (ADSCs) have therapeutic effects in inflammatory diseases. However, production of extracellular vesicles (EVs) from ADSCs is costly, inefficient, and time consuming. The anti-inflammatory properties of adipose tissue-derived EVs and other biogenic nanoparticles have not been explored. In this study, biogenic nanoparticles are obtained directly from lipoaspirate, an easily accessible and abundant source of biological material. Compared to ADSC-EVs, lipoaspirate nanoparticles (Lipo-NPs) take less time to process (hours compared to months) and cost less to produce (clinical-grade cell culture facilities are not required). The physicochemical characteristics and anti-inflammatory properties of Lipo-NPs are evaluated and compared to those of patient-matched ADSC-EVs. Moreover, guanabenz loading in Lipo-NPs is evaluated for enhanced anti-inflammatory effects. Apolipoprotein E and glycerolipids are enriched in Lipo-NPs compared to ADSC-EVs. Additionally, the uptake of Lipo-NPs in hepatocytes and macrophages is higher. Lipo-NPs and ADSC-EVs have comparable protective and anti-inflammatory effects. Specifically, Lipo-NPs reduce toll-like receptor 4-induced secretion of inflammatory cytokines in macrophages. Guanabenz-loaded Lipo-NPs further suppress inflammatory pathways, suggesting that this combination therapy can have promising applications for inflammatory diseases. |
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| DOI: | doi:10.1002/smll.201904064 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1002/smll.201904064 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201904064 |
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| | DOI: https://doi.org/10.1002/smll.201904064 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | anti-inflammation |
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| | exosome |
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| | extracellular vesicles |
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| | inflammation |
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| | lipoaspirate |
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| | microvesicle |
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| K10plus-PPN: | 1786608413 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Adipose-derived biogenic nanoparticles for suppression of inflammation / Tian, Ming [VerfasserIn]; 2020 (Online-Ressource)
