| Online-Ressource |
Verfasst von: | Schiedlmeier, Bernhard [VerfasserIn]  |
| Schilz, Andrea J. [VerfasserIn]  |
| Kühlcke, Klaus [VerfasserIn]  |
| Maier-Laufs, Stephanie [VerfasserIn]  |
| Baum, Christopher [VerfasserIn]  |
| Zeller, W. Jens [VerfasserIn]  |
| Eckert, Hans-Georg [VerfasserIn]  |
| Frühauf, Stefan [VerfasserIn]  |
Titel: | Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice |
Verf.angabe: | Bernd Schiedlmeier, Andrea J. Schilz, Klaus Kühlcke, Stephanie Laufs, Christopher Baum, W. Jens Zeller, Hans-Georg Eckert, and Stefan Fruehauf |
E-Jahr: | 2002 |
Jahr: | January 20, 2002 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 20.01.2022 |
Titel Quelle: | Enthalten in: Human gene therapy |
Ort Quelle: | New York, NY : Liebert, 1990 |
Jahr Quelle: | 2002 |
Band/Heft Quelle: | 13(2002), 2, Seite 233-242 |
ISSN Quelle: | 1557-7422 |
Abstract: | Myelosuppression is the main side effect of cancer chemotherapy. An improved rate of retroviral vector-mediated gene transfer to hematopoietic stem cells, shown in more recent clinical trials, has created the basis to test the concept of myeloprotective gene therapy. We transplanted clinical-scale human peripheral blood progenitor cell grafts (n = 2) transduced with retroviral vector SF91m3, which contains the human multidrug resistance 1 gene (MDR1), into nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. Engrafted mice of one cohort were protected from paclitaxel toxicity (p < 0.05) and we noted a similar trend in the second cohort. In paclitaxel-treated mice that had received gene-transduced cells we found a significant increase in gene marking (p < 0.05 - p < 0.01) or P-glycoprotein expression (p < 0.01) compared with their chemotherapy-naive counterparts. This is the first report showing that cytostatic drug resistance gene therapy can mediate chemoprotection of human clinically relevant stem cell populations with marrow engraftment potential. |
DOI: | doi:10.1089/10430340252769761 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1089/10430340252769761 |
| Volltext: https://www.liebertpub.com/doi/10.1089/10430340252769761 |
| DOI: https://doi.org/10.1089/10430340252769761 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1786609576 |
Verknüpfungen: | → Zeitschrift |
Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice / Schiedlmeier, Bernhard [VerfasserIn]; January 20, 2002 (Online-Ressource)