| |  Online-Ressource |
|---|
| Verfasst von: | Schiedlmeier, Bernhard [VerfasserIn]  |
|---|
| | Schilz, Andrea J. [VerfasserIn] |
|---|
| | Kühlcke, Klaus [VerfasserIn] |
|---|
| | Maier-Laufs, Stephanie [VerfasserIn] |
|---|
| | Baum, Christopher [VerfasserIn] |
|---|
| | Zeller, W. Jens [VerfasserIn] |
|---|
| | Eckert, Hans-Georg [VerfasserIn] |
|---|
| | Frühauf, Stefan [VerfasserIn] |
|---|
| Titel: | Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice |
|---|
| Verf.angabe: | Bernd Schiedlmeier, Andrea J. Schilz, Klaus Kühlcke, Stephanie Laufs, Christopher Baum, W. Jens Zeller, Hans-Georg Eckert, and Stefan Fruehauf |
|---|
| E-Jahr: | 2002 |
|---|
| Jahr: | January 20, 2002 |
|---|
| Umfang: | 10 S. |
|---|
| Fussnoten: | Gesehen am 20.01.2022 |
|---|
| Titel Quelle: | Enthalten in: Human gene therapy |
|---|
| Ort Quelle: | New York, NY : Liebert, 1990 |
|---|
| Jahr Quelle: | 2002 |
|---|
| Band/Heft Quelle: | 13(2002), 2, Seite 233-242 |
|---|
| ISSN Quelle: | 1557-7422 |
|---|
| Abstract: | Myelosuppression is the main side effect of cancer chemotherapy. An improved rate of retroviral vector-mediated gene transfer to hematopoietic stem cells, shown in more recent clinical trials, has created the basis to test the concept of myeloprotective gene therapy. We transplanted clinical-scale human peripheral blood progenitor cell grafts (n = 2) transduced with retroviral vector SF91m3, which contains the human multidrug resistance 1 gene (MDR1), into nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. Engrafted mice of one cohort were protected from paclitaxel toxicity (p < 0.05) and we noted a similar trend in the second cohort. In paclitaxel-treated mice that had received gene-transduced cells we found a significant increase in gene marking (p < 0.05 - p < 0.01) or P-glycoprotein expression (p < 0.01) compared with their chemotherapy-naive counterparts. This is the first report showing that cytostatic drug resistance gene therapy can mediate chemoprotection of human clinically relevant stem cell populations with marrow engraftment potential. |
|---|
| DOI: | doi:10.1089/10430340252769761 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1089/10430340252769761 |
|---|
| | Volltext: https://www.liebertpub.com/doi/10.1089/10430340252769761 |
|---|
| | DOI: https://doi.org/10.1089/10430340252769761 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1786609576 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice / Schiedlmeier, Bernhard [VerfasserIn]; January 20, 2002 (Online-Ressource)
