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| Verfasst von: | Peduzzi, Giulia [VerfasserIn]  |
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| | Gentiluomo, Manuel [VerfasserIn] |
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| | Tavano, Francesca [VerfasserIn] |
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| | Arcidiacono, Paolo Giorgio [VerfasserIn] |
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| | Ermini, Stefano [VerfasserIn] |
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| | Vodicka, Pavel [VerfasserIn] |
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| | Boggi, Ugo [VerfasserIn] |
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| | Cavestro, Giulia Martina [VerfasserIn] |
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| | Capurso, Gabriele [VerfasserIn] |
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| | Morelli, Luca [VerfasserIn] |
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| | Milanetto, Anna Caterina [VerfasserIn] |
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| | Pezzilli, Raffaele [VerfasserIn] |
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| | Lawlor, Rita T. [VerfasserIn] |
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| | Carrara, Silvia [VerfasserIn] |
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| | Lovecek, Martin [VerfasserIn] |
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| | Souček, Pavel [VerfasserIn] |
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| | Guo, Feng [VerfasserIn] |
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| | Hackert, Thilo [VerfasserIn] |
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| | Uzunoğlu, Faik G. [VerfasserIn] |
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| | Gazouli, Maria [VerfasserIn] |
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| | Párniczky, Andrea [VerfasserIn] |
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| | Kupcinskas, Juozas [VerfasserIn] |
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| | Bijlsma, Maarten F. [VerfasserIn] |
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| | Bueno-de-Mesquita, Bas [VerfasserIn] |
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| | Vermeulen, Roel [VerfasserIn] |
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| | Eijck, Casper H. J. van [VerfasserIn] |
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| | Jamroziak, Krzysztof [VerfasserIn] |
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| | Talar-Wojnarowska, Renata [VerfasserIn] |
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| | Greenhalf, William [VerfasserIn] |
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| | Gioffreda, Domenica [VerfasserIn] |
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| | Petrone, Maria C. [VerfasserIn] |
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| | Landi, Stefano [VerfasserIn] |
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| | Archibugi, Livia [VerfasserIn] |
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| | Puzzono, Marta [VerfasserIn] |
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| | Funel, Niccola [VerfasserIn] |
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| | Sperti, Cosimo [VerfasserIn] |
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| | Piredda, Maria L. [VerfasserIn] |
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| | Mohelnikova-Duchonova, Beatrice [VerfasserIn] |
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| | Lu, Ye [VerfasserIn] |
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| | Hlaváč, Viktor [VerfasserIn] |
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| | Gao, Xin [VerfasserIn] |
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| | Schneider, Martin [VerfasserIn] |
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| | Izbicki, Jakob R. [VerfasserIn] |
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| | Theodoropoulos, George [VerfasserIn] |
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| | Bunduc, Stefania [VerfasserIn] |
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| | Kreivenaite, Edita [VerfasserIn] |
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| | Busch, Olivier R. [VerfasserIn] |
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| | Małecka-Panas, Ewa [VerfasserIn] |
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| | Costello, Eithne [VerfasserIn] |
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| | Perri, Francesco [VerfasserIn] |
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| | Testoni, Sabrina Gloria Giulia [VerfasserIn] |
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| | Vanella, Giuseppe [VerfasserIn] |
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| | Pasquali, Claudio [VerfasserIn] |
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| | Oliverius, Martin [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| | Loos, Martin [VerfasserIn] |
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| | Götz, Mara [VerfasserIn] |
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| | Georgiou, Konstantinos [VerfasserIn] |
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| | Erőss, Bálint [VerfasserIn] |
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| | Maiello, Evaristo [VerfasserIn] |
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| | Szentesi, Andrea [VerfasserIn] |
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| | Bazzocchi, Francesca [VerfasserIn] |
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| | Basso, Daniela [VerfasserIn] |
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| | Neoptolemos, John P. [VerfasserIn] |
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| | Hegyi, Péter [VerfasserIn] |
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| | Kiudelis, Vytautas [VerfasserIn] |
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| | Canzian, Federico [VerfasserIn] |
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| | Campa, Daniele [VerfasserIn] |
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| Titel: | Genetic polymorphisms involved in mitochondrial metabolism and pancreatic cancer risk |
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| Verf.angabe: | Giulia Peduzzi, Manuel Gentiluomo, Francesca Tavano, Paolo Giorgio Arcidiacono, Stefano Ermini, Pavel Vodicka, Ugo Boggi, Giulia Martina Cavestro, Gabriele Capurso, Luca Morelli, Anna Caterina Milanetto, Raffaele Pezzilli, Rita T. Lawlor, Silvia Carrara, Martin Lovecek, Pavel Souček, Feng Guo, Thilo Hackert, Faik G. Uzunoğlu, Maria Gazouli, Andrea Párniczky, Juozas Kupcinskas, Maarten F. Bijlsma, Bas Bueno-de-Mesquita, Roel Vermeulen, Casper H.J. van Eijck, Krzysztof Jamroziak, Renata Talar-Wojnarowska, William Greenhalf, Domenica Gioffreda, Maria C. Petrone, Stefano Landi, Livia Archibugi, Marta Puzzono, Niccola Funel, Cosimo Sperti, Maria L. Piredda, Beatrice Mohelnikova-Duchonova, Ye Lu, Viktor Hlaváč, Xin Gao, Martin Schneider, Jakob R. Izbicki, George Theodoropoulos, Stefania Bunduc, Edita Kreivenaite, Olivier R. Busch, Ewa Małecka-Panas, Eithne Costello, Francesco Perri, Sabrina Gloria Giulia Testoni, Giuseppe Vanella, Claudio Pasquali, Martin Oliverius, Hermann Brenner, Martin Loos, Mara Götz, Konstantinos Georgiou, Bálint Erőss, Evaristo Maiello, Andrea Szentesi, Francesca Bazzocchi, Daniela Basso, John P. Neoptolemos, Péter Hegyi, Vytautas Kiudelis, Federico Canzian, and Daniele Campa |
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| E-Jahr: | 2021 |
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| Jahr: | September 15, 2021 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 21.01.2021 |
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| Titel Quelle: | Enthalten in: Cancer epidemiology, biomarkers & prevention |
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| Ort Quelle: | Philadelphia, Pa. : AACR, 1991 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 30(2021), 12, Seite 2342-2345 |
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| ISSN Quelle: | 1538-7755 |
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| Abstract: | Background: The mitochondrial metabolism has been associated with pancreatic ductal adenocarcinoma (PDAC) risk. Recent evidence also suggests the involvement of the genetic variability of the mitochondrial function in several traits involved in PDAC etiology. However, a systematic investigation of the genetic variability of mitochondrial genome (mtSNP) and of all the nuclear genes involved in its functioning (n-mtSNPs) has never been reported. - Methods: We conducted a two-phase association study of mtSNPs and n-mtSNPs to assess their effect on PDAC risk. We analyzed 35,297 n-mtSNPs and 101 mtSNPs in up to 55,870 individuals (12,884 PDAC cases and 42,986 controls). In addition, we also conducted a gene-based analysis on 1,588 genes involved in mitochondrial metabolism using Multi-marker Analysis of GenoMic Annotation (MAGMA) software. - Results: In the discovery phase, we identified 49 n-mtSNPs and no mtSNPs associated with PDAC risk (P < 0.05). In the second phase, none of the findings were replicated. In the gene-level analysis, we observed that three genes (TERT, SUGCT, and SURF1) involved in the mitochondrial metabolism showed an association below the Bonferroni-corrected threshold of statistical significance (P = 0.05/1588 = 3.1 × 10−5). - Conclusions: Even though the mitochondrial metabolism might be involved in PDAC etiology, our results, obtained in a study with one of the largest sample sizes to date, show that neither n-mtSNPs nor mtSNPs are associated with PDAC risk. - Impact: This large case-control study does not support a role of the genetic variability of the mitochondrial function in PDAC risk. |
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| DOI: | doi:10.1158/1055-9965.EPI-21-0353 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1158/1055-9965.EPI-21-0353 |
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| | Volltext: https://cebp.aacrjournals.org/content/30/12/2342 |
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| | DOI: https://doi.org/10.1158/1055-9965.EPI-21-0353 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1786855372 |
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| Verknüpfungen: | → Zeitschrift |
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Genetic polymorphisms involved in mitochondrial metabolism and pancreatic cancer risk / Peduzzi, Giulia [VerfasserIn]; September 15, 2021 (Online-Ressource)
