| Online-Ressource |
Verfasst von: | Kristen, Arnt [VerfasserIn]  |
| Dengler, Thomas [VerfasserIn]  |
| Hegenbart, Ute [VerfasserIn]  |
| Schönland, Stefan [VerfasserIn]  |
| Goldschmidt, Hartmut [VerfasserIn]  |
| Sack, Falk-Udo [VerfasserIn]  |
| Voss, Frederik [VerfasserIn]  |
| Becker, Rüdiger [VerfasserIn]  |
| Katus, Hugo [VerfasserIn]  |
| Bauer, Alexander [VerfasserIn]  |
Titel: | Prophylactic implantation of cardioverter-defibrillator in patients with severe cardiac amyloidosis and high risk for sudden cardiac death |
Verf.angabe: | Arnt V. Kristen, Thomas J. Dengler, Ute Hegenbart, Stefan O. Schonland, Hartmut Goldschmidt, Falk-Udo Sack, Frederik Voss, Rüdiger Becker, Hugo A. Katus, Alexander Bauer |
E-Jahr: | 2008 |
Jahr: | [February 2008] |
Umfang: | 6 S. |
Illustrationen: | 1 Diagramm |
Fussnoten: | Gesehen am 21.01.2022 |
Titel Quelle: | Enthalten in: Heart rhythm |
Ort Quelle: | New York, NY [u.a.] : Elsevier, 2004 |
Jahr Quelle: | 2008 |
Band/Heft Quelle: | 5(2008), 2, Seite 235-240 |
ISSN Quelle: | 1556-3871 |
Abstract: | Background - Cardiac light-chain amyloidosis carries a high risk for death predominantly from progressive cardiomyopathy or sudden death (SCD). Independent risk factors for SCD are syncope and complex nonsustained ventricular arrhythmias. - Objective - The purpose of this study was to test whether prophylactic placement of an implantable cardioverter-defibrillator (ICD) reduces SCD in patients with cardiac amyloidosis. - Methods - Nineteen patients with histologically proven cardiac amyloidosis and a history of syncope and/or ventricular extra beats (Lown grade IVa or higher) received an ICD. - Results - During a mean follow-up of 811 ± 151 days, two patients with sustained ventricular tachyarrhythmias were successfully treated by the ICD. Two patients underwent heart transplantation, and seven patients died due to electromechanical dissociation (n = 6) or glioblastoma (n = 1). Nonsurvivors more often showed progression of left ventricular wall thickness, low-voltage pattern, ventricular arrhythmias (Lown grade IVa or higher), and higher N-terminal pro-brain natriuretic peptide levels than did survivors. Bradycardias requiring ventricular pacing (VVI 40/min <1%, DDD 60/min 6% ± 1%) occurred only rarely. - Conclusion - Patients with cardiac amyloidosis predominantly die as a result of electromechanical dissociation and other diagnoses not amenable to ICD therapy. Selected patients with cardiac amyloidosis may benefit from ICD placement. Better predictors of arrhythmia-associated SCD and randomized trials are required to elucidate the impact of ICD placement in high-risk patients with cardiac amyloidosis. |
DOI: | doi:10.1016/j.hrthm.2007.10.016 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.hrthm.2007.10.016 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S1547527107010260 |
| DOI: https://doi.org/10.1016/j.hrthm.2007.10.016 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Amyloid |
| Heart failure |
| Implantable cardioverter-defibrillator |
| Sudden death |
| Survival |
K10plus-PPN: | 1786859084 |
Verknüpfungen: | → Zeitschrift |
Prophylactic implantation of cardioverter-defibrillator in patients with severe cardiac amyloidosis and high risk for sudden cardiac death / Kristen, Arnt [VerfasserIn]; [February 2008] (Online-Ressource)