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Status: Bibliographieeintrag

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Verfasst von:Kristen, Arnt [VerfasserIn]   i
 Dengler, Thomas [VerfasserIn]   i
 Hegenbart, Ute [VerfasserIn]   i
 Schönland, Stefan [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Sack, Falk-Udo [VerfasserIn]   i
 Voss, Frederik [VerfasserIn]   i
 Becker, Rüdiger [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
 Bauer, Alexander [VerfasserIn]   i
Titel:Prophylactic implantation of cardioverter-defibrillator in patients with severe cardiac amyloidosis and high risk for sudden cardiac death
Verf.angabe:Arnt V. Kristen, Thomas J. Dengler, Ute Hegenbart, Stefan O. Schonland, Hartmut Goldschmidt, Falk-Udo Sack, Frederik Voss, Rüdiger Becker, Hugo A. Katus, Alexander Bauer
E-Jahr:2008
Jahr:[February 2008]
Umfang:6 S.
Illustrationen:1 Diagramm
Fussnoten:Gesehen am 21.01.2022
Titel Quelle:Enthalten in: Heart rhythm
Ort Quelle:New York, NY [u.a.] : Elsevier, 2004
Jahr Quelle:2008
Band/Heft Quelle:5(2008), 2, Seite 235-240
ISSN Quelle:1556-3871
Abstract:Background - Cardiac light-chain amyloidosis carries a high risk for death predominantly from progressive cardiomyopathy or sudden death (SCD). Independent risk factors for SCD are syncope and complex nonsustained ventricular arrhythmias. - Objective - The purpose of this study was to test whether prophylactic placement of an implantable cardioverter-defibrillator (ICD) reduces SCD in patients with cardiac amyloidosis. - Methods - Nineteen patients with histologically proven cardiac amyloidosis and a history of syncope and/or ventricular extra beats (Lown grade IVa or higher) received an ICD. - Results - During a mean follow-up of 811 ± 151 days, two patients with sustained ventricular tachyarrhythmias were successfully treated by the ICD. Two patients underwent heart transplantation, and seven patients died due to electromechanical dissociation (n = 6) or glioblastoma (n = 1). Nonsurvivors more often showed progression of left ventricular wall thickness, low-voltage pattern, ventricular arrhythmias (Lown grade IVa or higher), and higher N-terminal pro-brain natriuretic peptide levels than did survivors. Bradycardias requiring ventricular pacing (VVI 40/min <1%, DDD 60/min 6% ± 1%) occurred only rarely. - Conclusion - Patients with cardiac amyloidosis predominantly die as a result of electromechanical dissociation and other diagnoses not amenable to ICD therapy. Selected patients with cardiac amyloidosis may benefit from ICD placement. Better predictors of arrhythmia-associated SCD and randomized trials are required to elucidate the impact of ICD placement in high-risk patients with cardiac amyloidosis.
DOI:doi:10.1016/j.hrthm.2007.10.016
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.hrthm.2007.10.016
 Volltext: https://www.sciencedirect.com/science/article/pii/S1547527107010260
 DOI: https://doi.org/10.1016/j.hrthm.2007.10.016
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Amyloid
 Heart failure
 Implantable cardioverter-defibrillator
 Sudden death
 Survival
K10plus-PPN:1786859084
Verknüpfungen:→ Zeitschrift

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