Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Möhler, Thomas [VerfasserIn]   i
 Sauer, Sandra [VerfasserIn]   i
 Witzel, Maximilian G. W. [VerfasserIn]   i
 Andrulis, Mindaugas [VerfasserIn]   i
 Garcia-Vallejo, Juan J. [VerfasserIn]   i
 Grobholz, Rainer [VerfasserIn]   i
 Willhauck-Fleckenstein, Martina [VerfasserIn]   i
 Greiner, Axel [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Schwartz-Albiez, Reinhard [VerfasserIn]   i
Titel:Involvement of α 1-2-fucosyltransferase I (FUT1) and surface-expressed lewisy (CD174) in first endothelial cell-cell contacts during angiogenesis
Verf.angabe:Thomas M. Moehler, Sandra Sauer, Maximilian Witzel, Mindaugas Andrulis, Juan J. Garcia-Vallejo, Rainer Grobholz, Martina Willhauck-Fleckenstein, Axel Greiner, Hartmut Goldschmidt, and Reinhard Schwartz-Albiez
E-Jahr:2008
Jahr:18 January 2008
Umfang:10 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 21.01.2022
Titel Quelle:Enthalten in: Journal of cellular physiology
Ort Quelle:New York, NY [u.a.] : Wiley-Liss, 1932
Jahr Quelle:2008
Band/Heft Quelle:215(2008), 1, Seite 27-36
ISSN Quelle:1097-4652
Abstract:During the initiation of tumor associated angiogenesis endothelial cells migrate, adhere to extracellular matrix and form cell-cell contacts. Humoral factors of malignant cells conduct this process. We investigated whether cell surface expression of the carbohydrate blood group determinant Lewisy (CD174) and its precursor structure H2 (CD173) on endothelial cells is influenced by soluble factors of tumor cells. Using a bone marrow derived endothelial cell line we observed an enhanced expression of CD173/CD174 and transcription of FUT1, the key enzyme for their synthesis, after treatment with tumor necrosis factor-α (TNF-α) or conditioned supernatants of the leukemia cell line KG1a. CD173/CD174 are concentrated on pseudopodial extensions responsible for initial contacts between endothelial cells. Endothelial migration induced by TNF-α could be diminished by antibodies to CD174 as well as by siRNA induced downmodulation of FUT1 transcription. Endothelial FUT1-siRNA-transfectants displayed impaired in vitro angiogenesis when cultivated on extracellular matrix and in spheroid assays. In vivo upregulation of CD174 expression was observed immunocytologically in capillaries of tumor-infiltrated tissue. Together, our observations point to a tumor induced transcription of endothelial FUT1 and consequently an enhanced expression of CD174 which is involved in migration and early cell-cell contacts during tumor associated angiogenesis. J. Cell. Physiol. 215: 27-36, 2008. © 2008 Wiley-Liss, Inc.
DOI:doi:10.1002/jcp.21285
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/jcp.21285
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.21285
 DOI: https://doi.org/10.1002/jcp.21285
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1786886316
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68869722   QR-Code
zum Seitenanfang