| |  Online-Ressource |
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| Verfasst von: | Hessen, Eline [VerfasserIn]  |
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| | Makocki, Sebastian [VerfasserIn] |
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| | van der Heide, Uulke A. [VerfasserIn] |
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| | Jasperse, Bas [VerfasserIn] |
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| | Lutkenhaus, Lotte J. [VerfasserIn] |
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| | Lamers, Emmy [VerfasserIn] |
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| | Damen, Eugène [VerfasserIn] |
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| | Troost, Esther Gera Cornelia [VerfasserIn] |
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| | Borst, Gerben R. [VerfasserIn] |
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| Titel: | The impact of anatomical changes during photon or proton based radiation treatment on tumor dose in glioblastoma dose escalation trials |
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| Verf.angabe: | Eline D. Hessen, Sebastian Makocki, Uulke A. van der Heide, Bas Jasperse, Lotte J. Lutkenhaus, Emmy Lamers, Eugène Damen, Esther G.C. Troost, Gerben R. Borst |
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| E-Jahr: | 2021 |
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| Jahr: | 28 September 2021 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 22.01.2022 |
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| Titel Quelle: | Enthalten in: Radiotherapy and oncology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1983 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 164(2021), Seite 202-208 |
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| ISSN Quelle: | 1879-0887 |
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| Abstract: | Purpose/Objective - Most dose-escalation trials in glioblastoma patients integrate the escalated dose throughout the standard course by targeting a specific subvolume. We hypothesize that anatomical changes during irradiation may affect the dose coverage of this subvolume for both proton- and photon-based radiotherapy. - Material and Methods - For 24 glioblastoma patients a photon- and proton-based dose escalation treatment plan (of 75 Gy/30 fr) was simulated on the dedicated radiotherapy planning MRI obtained before treatment. The escalated dose was planned to cover the resection cavity and/or contrast enhancing lesion on the T1w post-gadolinium MRI sequence. To analyze the effect of anatomical changes during treatment, we evaluated on an additional MRI that was obtained during treatment the changes of the dose distribution on this specific high dose region. - Results - The median time between the planning MRI and additional MRI was 26 days (range 16-37 days). The median time between the planning MRI and start of radiotherapy was relatively short (7 days, range 3-11 days). In 3 patients (12.5%) changes were observed which resulted in a substantial deterioration of both the photon and proton treatment plans. All these patients underwent a subtotal resection, and a decrease in dose coverage of more than 5% and 10% was observed for the photon- and proton-based treatment plans, respectively. - Conclusion - Our study showed that only for a limited number of patients anatomical changes during photon or proton based radiotherapy resulted in a potentially clinically relevant underdosage in the subvolume. Therefore, volume changes during treatment are unlikely to be responsible for the negative outcome of dose-escalation studies. |
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| DOI: | doi:10.1016/j.radonc.2021.09.022 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.radonc.2021.09.022 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0167814021067451 |
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| | DOI: https://doi.org/10.1016/j.radonc.2021.09.022 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Anatomical changes |
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| | Dose escalation trials |
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| | Glioblastoma |
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| | Radiotherapy |
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| | Repeated MRI |
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| | Target volume changes |
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| K10plus-PPN: | 1786951746 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ impact of anatomical changes during photon or proton based radiation treatment on tumor dose in glioblastoma dose escalation trials / Hessen, Eline [VerfasserIn]; 28 September 2021 (Online-Ressource)
