| |  Online-Ressource |
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| Verfasst von: | Rücker, Frank Gert [VerfasserIn]  |
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| | Russ, A. C. [VerfasserIn] |
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| | Cocciardi, S. [VerfasserIn] |
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| | Kett, H. [VerfasserIn] |
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| | Schlenk, R. F. [VerfasserIn] |
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| | Botzenhardt, U. [VerfasserIn] |
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| | Langer, C. [VerfasserIn] |
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| | Krauter, J. [VerfasserIn] |
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| | Fröhling, S. [VerfasserIn] |
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| | Schlegelberger, B. [VerfasserIn] |
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| | Ganser, A. [VerfasserIn] |
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| | Lichter, Peter [VerfasserIn] |
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| | Zenz, T. [VerfasserIn] |
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| | Döhner, H. [VerfasserIn] |
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| | Döhner, K. [VerfasserIn] |
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| | Bullinger, L. [VerfasserIn] |
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| Titel: | Altered miRNA and gene expression in acute myeloid leukemia with complex karyotype identify networks of prognostic relevance |
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| Verf.angabe: | F.G. Rücker, A.C. Russ, S. Cocciardi, H. Kett, R.F. Schlenk, U. Botzenhardt, C. Langer, J. Krauter, S. Fröhling, B. Schlegelberger, A. Ganser, P. Lichter, T. Zenz, H. Döhner, K. Döhner and L. Bullinger |
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| Jahr: | 2013 |
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| Umfang: | 9 S. |
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| Fussnoten: | Advance online publication, 10 August 2012 ; Gesehen am 24.01.2022 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 27(2013), 2, Seite 353-361 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | Recently, the p53-miR-34a network has been identified to have an important role in tumorigenesis. As in acute myeloid leukemia with complex karyotype (CK-AML) TP53 alterations are the most common known molecular lesion, we further analyzed the p53-miR-34a axis in a large cohort of CK-AML with known TP53 status (TP53altered, n=57; TP53unaltered, n=31; altered indicates loss and/or mutation of TP53). Profiling microRNA (miRNA) expression delineated TP53 alteration-associated miRNA profiles, and identified miR-34a and miR-100 as the most significantly down- and upregulated miRNA, respectively. Moreover, we found a distinct miR-34a expression-linked gene expression profile enriched for genes belonging to p53-associated pathways, and implicated in cell cycle progression or apoptosis. Clinically, low miR-34a expression and TP53 alterations predicted for chemotherapy resistance and inferior outcome. Notably, in TP53unaltered CK-AML, high miR-34a expression predicted for inferior overall survival (OS), whereas in TP53biallelic altered CK-AML, high miR-34a expression pointed to better OS. Thus, detailed molecular profiling links impaired p53 to decreased miR-34a expression, but also identifies p53-independent miR-34a induction mechanisms as shown in TP53biallelic altered cell lines treated with 15-deoxy-Δ12,14-prostaglandin. An improved understanding of this mechanism might provide novel therapeutic options to restore miR-34a function and thereby induce cell cycle arrest and apoptosis in TP53altered CK-AML. |
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| DOI: | doi:10.1038/leu.2012.208 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/leu.2012.208 |
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| | Volltext: https://www.nature.com/articles/leu2012208 |
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| | DOI: https://doi.org/10.1038/leu.2012.208 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Acute myeloid leukaemia |
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| | Cancer genomics |
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| | Chemotherapy |
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| | miRNAs |
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| K10plus-PPN: | 178696418X |
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| Verknüpfungen: | → Zeitschrift |
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Altered miRNA and gene expression in acute myeloid leukemia with complex karyotype identify networks of prognostic relevance / Rücker, Frank Gert [VerfasserIn]; 2013 (Online-Ressource)
