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Status: Bibliographieeintrag

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Verfasst von:Phelan, Kevin [VerfasserIn]   i
 Shwe, U. Thaung [VerfasserIn]   i
 Abramowitz, Joel [VerfasserIn]   i
 Wu, Hong [VerfasserIn]   i
 Rhee, Sung W. [VerfasserIn]   i
 Howell, Matthew D. [VerfasserIn]   i
 Gottschall, Paul E. [VerfasserIn]   i
 Freichel, Marc [VerfasserIn]   i
 Flockerzi, Veit [VerfasserIn]   i
 Birnbaumer, Lutz [VerfasserIn]   i
 Zheng, Fang [VerfasserIn]   i
Titel:Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms
Verf.angabe:Kevin D. Phelan, U. Thaung Shwe, Joel Abramowitz, Hong Wu, Sung W. Rhee, Matthew D. Howell, Paul E. Gottschall, Marc Freichel, Veit Flockerzi, Lutz Birnbaumer and Fang Zheng
E-Jahr:2013
Jahr:January 17, 2013
Umfang:10 S.
Fussnoten:Gesehen am 24.01.2022
Titel Quelle:Enthalten in: Molecular pharmacology
Ort Quelle:Bethesda, Md. : ASPET, 1965
Jahr Quelle:2013
Band/Heft Quelle:83(2013), 2, Seite 429-438
ISSN Quelle:1521-0111
Abstract:Seizures are the manifestation of highly synchronized burst firing of a large population of cortical neurons. Epileptiform bursts with an underlying plateau potential in neurons are a cellular correlate of seizures. Emerging evidence suggests that the plateau potential is mediated by neuronal canonical transient receptor potential (TRPC) channels composed of members of the TRPC1/4/5 subgroup. We previously showed that TRPC1/4 double-knockout (DKO) mice lack epileptiform bursting in lateral septal neurons and exhibit reduced seizure-induced neuronal cell death, but surprisingly have unaltered pilocarpine-induced seizures. Here, we report that TRPC5 knockout (KO) mice exhibit both significantly reduced seizures and minimal seizure-induced neuronal cell death in the hippocampus. Interestingly, epileptiform bursting induced by agonists for metabotropic glutamate receptors in the hippocampal CA1 area is unaltered in TRPC5 KO mice, but is abolished in TRPC1 KO and TRPC1/4 DKO mice. In contrast, long-term potentiation is greatly reduced in TRPC5 KO mice, but is normal in TRPC1 KO and TRPC1/4 DKO mice. The distinct changes from these knockouts suggest that TRPC5 and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Furthermore, the reduced seizure and excitotoxicity and normal spatial learning exhibited in TRPC5 KO mice suggest that TRPC5 is a promising novel molecular target for new therapy.
DOI:doi:10.1124/mol.112.082271
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1124/mol.112.082271
 Volltext: https://molpharm.aspetjournals.org/content/83/2/429
 DOI: https://doi.org/10.1124/mol.112.082271
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:178696564X
Verknüpfungen:→ Zeitschrift

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