| |  Online-Ressource |
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| Verfasst von: | Salaverria, Itziar [VerfasserIn]  |
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| | Martin-Guerrero, Idoia [VerfasserIn] |
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| | Burkhardt, Birgit [VerfasserIn] |
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| | Kreuz, Markus [VerfasserIn] |
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| | Zenz, Thorsten [VerfasserIn] |
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| | Oschlies, Ilske [VerfasserIn] |
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| | Arnold, Norbert [VerfasserIn] |
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| | Baudis, Michael [VerfasserIn] |
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| | Bens, Susanne [VerfasserIn] |
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| | García-Orad, Africa [VerfasserIn] |
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| | Lisfeld, Jasmin [VerfasserIn] |
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| | Schwaenen, Carsten [VerfasserIn] |
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| | Szczepanowski, Monika [VerfasserIn] |
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| | Wessendorf, Swen [VerfasserIn] |
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| | Pfreundschuh, Michael [VerfasserIn] |
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| | Trümper, Lorenz [VerfasserIn] |
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| | Klapper, Wolfram [VerfasserIn] |
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| | Siebert, Reiner [VerfasserIn] |
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| Titel: | High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas |
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| Verf.angabe: | Itziar Salaverria, Idoia Martin-Guerrero, Birgit Burkhardt, Markus Kreuz, Thorsten Zenz, Ilske Oschlies, Norbert Arnold, Michael Baudis, Susanne Bens, Africa García-Orad, Jasmin Lisfeld, Carsten Schwaenen, Monika Szczepanowski, Swen Wessendorf, Michael Pfreundschuh, Lorenz Trümper, Wolfram Klapper, Reiner Siebert |
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| Jahr: | 2013 |
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| Umfang: | 6 S. |
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| Fussnoten: | First published: 17 October 2012 ; Gesehen am 26.01.2022 |
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| Titel Quelle: | Enthalten in: Genes, chromosomes & cancer |
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| Ort Quelle: | New York, NY : Wiley-Liss, 1989 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 52(2013), 2 vom: Feb., Seite 150-155 |
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| ISSN Quelle: | 1098-2264 |
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| Abstract: | Translocations affecting chromosome subband 6p25.3 containing the IRF4 gene have been recently described as characteristic alterations in a molecularly distinct subset of germinal center B-cell-derived lymphomas. Secondary changes have yet only been described in few of these lymphomas. Here, we performed array-comparative genomic hybridization and molecular inversion probe microarray analyses on DNA from 12 formalin-fixed paraffin-embedded and two fresh-frozen IRF4 translocation-positive lymphomas, which together with the previously published data on nine cases allowed the extension of copy number analyses to a total of 23 of these lymphomas. All except one case carried chromosomal imbalances, most frequently gains in Xq28, 11q22.3-qter, and 7q32.1-qter and losses in 6q13-16.1, 15q14-22.31, and 17p. No recurrent copy-neutral losses of heterozygosity were observed. TP53 point mutations were detected in three of six cases with loss of 17p. Overall this study unravels a recurrent pattern of secondary genetic alterations in IRF4 translocation-positive lymphomas. © 2012 Wiley Periodicals, Inc. |
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| DOI: | doi:10.1002/gcc.22014 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/gcc.22014 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.22014 |
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| | DOI: https://doi.org/10.1002/gcc.22014 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 178719020X |
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| Verknüpfungen: | → Zeitschrift |
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High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas / Salaverria, Itziar [VerfasserIn]; 2013 (Online-Ressource)
