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Verfasst von:Nolte, Florian [VerfasserIn]   i
 Giehl, Michelle [VerfasserIn]   i
 Prinzhorn, Wiltrud [VerfasserIn]   i
 Nowak, Verena [VerfasserIn]   i
 Schumann, Christiane [VerfasserIn]   i
 Nowak, Daniel [VerfasserIn]   i
 Mossner, Maximilian [VerfasserIn]   i
 Popp, Henning [VerfasserIn]   i
 Schulze, Torsten [VerfasserIn]   i
 Klein, Stefan [VerfasserIn]   i
 Seifarth, Wolfgang [VerfasserIn]   i
 Hofmann, Wolf-Karsten [VerfasserIn]   i
 Fabarius, Alice [VerfasserIn]   i
Titel:Centrosome aberrations in bone marrow cells from patients with myelodysplastic syndromes correlate with chromosomal instability
Verf.angabe:Florian Nolte, Michelle Giehl, Wiltrud Haass, Verena Nowak, Christiane Schumann, Daniel Nowak, Maximillian Mossner, Henning D. Popp, Torsten J. Schulze, Stefan Klein, Wolfgang Seifarth, Wolf-Karsten Hofmann, Alice Fabarius
E-Jahr:2013
Jahr:05 May 2013
Umfang:9 S.
Fussnoten:Gesehen am 26.01.2022
Titel Quelle:Enthalten in: Annals of hematology
Ort Quelle:Berlin : Springer, 1991
Jahr Quelle:2013
Band/Heft Quelle:92(2013), 10, Seite 1325-1333
ISSN Quelle:1432-0584
Abstract:Centrosomes play important roles in the maintenance of genetic stability and centrosomal aberrations are a hallmark of cancer. Deregulation of centriole duplication leads to supernumerary centrosomes, sister chromatid missegregation and could result in chromosomal instability (CIN) and aneuploidy. CIN is a common feature in at least 45 % of patients with myelodysplastic syndromes (MDS). Therefore, we sought to investigate the centrosomal status and its role for development of CIN in bone marrow (BM) cells of MDS patients. BM cells of 34 MDS patients were examined cytogenetically. Furthermore, cells were immunostained with a centrosome-specific antibody to pericentrin to analyze the centrosomal status. Umbilical cord blood specimens and BM cells of healthy persons (n = 11 and n = 4) served as controls. In addition, the protein expression of the protease separase responsible for genetic stability was examined by western blot analysis. Centrosome abnormalities were detected in 10 % (range, 4-17 %) of cells of MDS samples, but in only 2 % (range, 0-4 %) of cells of healthy controls. Normal karyotypes were found in control cells and in BM cells of 16/34 MDS patients. The incidence of centrosomal alterations was higher in BM cells of patients with cytogenetic alterations (mean, 12 %) compared to BM cells of patients without cytogenetic changes (mean, 7 %). Our results indicate that centrosome alterations are a common and early detectable feature in MDS patients and may contribute to the acquisition of chromosomal aberrations. We assume that centrosome defects could be involved in disease progression and may serve as a future prognostic marker.
DOI:doi:10.1007/s00277-013-1772-7
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1007/s00277-013-1772-7
 DOI: https://doi.org/10.1007/s00277-013-1772-7
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Erscheint auch als : Druck-Ausgabe: Nolte, Florian, 1976 - : Centrosome aberrations in bone marrow cells from patients with myelodysplastic syndromes correlate with chromosomal instability. - 2013
K10plus-PPN:1787209253
Verknüpfungen:→ Zeitschrift

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