Status: Bibliographieeintrag
Standort: ---
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| Online-Ressource |
Verfasst von: | Swidergall, Marc [VerfasserIn]  |
| Ernst, Andreas M. [VerfasserIn]  |
| Ernst, Joachim F. [VerfasserIn]  |
Titel: | Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides |
Verf.angabe: | Marc Swidergall, Andreas M. Ernst, and Joachim F. Ernst |
E-Jahr: | 2013 |
Jahr: | 3 June 2013 |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 27.01.2022 |
Titel Quelle: | Enthalten in: Antimicrobial agents and chemotherapy |
Ort Quelle: | Washington, DC : Soc., 1972 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 57(2013), 8, Seite 3917-3922 |
ISSN Quelle: | 1098-6596 |
Abstract: | The human fungal pathogen Candida albicans releases a large glycofragment of the Msb2 surface protein (Msb2*) into the growth environment, which protects against the action of human antimicrobial peptides (AMPs) LL-37 and histatin-5. Quantitation of Msb2*/LL-37 interactions by microscale thermophoresis revealed high-affinity binding (dissociation constant [KD] = 73 nM), which was lost or greatly diminished by lack of O-glycosylation or by Msb2* denaturation. Msb2* also interacted with human α- and β-defensins and protected C. albicans against these AMPs. In addition, the lipopeptide antibiotic daptomycin was bound and inactivated by Msb2*, which prevented the killing of bacterial pathogens Staphylococcus aureus, Enterococcus faecalis, and Corynebacterium pseudodiphtheriticum. In coculturings or mixed biofilms of S. aureus with C. albicans wild-type but not msb2 mutant strains, the protective effects of Msb2* on the bactericidal action of daptomycin were demonstrated. These results suggest that tight binding of shed Msb2* to AMPs that occurs during bacterial coinfections with C. albicans compromises antibacterial therapy by inactivating a relevant reserve antibiotic. |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://journals.asm.org/doi/abs/10.1128/AAC.00862-13 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1787313581 |
Verknüpfungen: | → Zeitschrift |
Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides / Swidergall, Marc [VerfasserIn]; 3 June 2013 (Online-Ressource)
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